tert-Butyl 1-piperazinecarboxylate
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tert-Butyl 1-piperazinecarboxylate 속성
- 녹는점
- 43-47 °C(lit.)
- 끓는 점
- 98-100
- 밀도
- 1.030±0.06 g/cm3(Predicted)
- 인화점
- >230 °F
- 저장 조건
- Keep in dark place,Inert atmosphere,2-8°C
- 용해도
- DMSO에 용해됨
- 산도 계수 (pKa)
- 8.45±0.10(Predicted)
- 물리적 상태
- 저융점 결정질 덩어리
- 색상
- 흰색에서 밝은 노란색
- 수용성
- 에틸 아세테이트, 메탄올 및 물에 용해됩니다.
- 감도
- Air Sensitive
- BRN
- 879985
- InChIKey
- CWXPZXBSDSIRCS-UHFFFAOYSA-N
- CAS 데이터베이스
- 57260-71-6(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xi | ||
---|---|---|---|
위험 카페고리 넘버 | 36/37/38 | ||
안전지침서 | 26-36 | ||
유엔번호(UN No.) | 3263 | ||
WGK 독일 | 3 | ||
F 고인화성물질 | 3-10-34 | ||
위험 등급 | IRRITANT | ||
HS 번호 | 29335995 |
tert-Butyl 1-piperazinecarboxylate C화학적 특성, 용도, 생산
화학적 성질
Waxy Solid용도
1-Boc-piperazine undergoes Buchwald-Hartwig amination with various aryl halides to form corresponding amine derivatives. It can be used to synthesize monosubstituted piperazine intermediates of many bioactive molecules and piperazine containing drug substances, such as trazodone.주요 응용
Tert-Butyl 1-piperazinecarboxylate, also known as Olaparib Impurity 7, is an impurity of Olaparib. Olaparib is used alone or in combination with bevacizumab (Avastin) to help maintain the response of certain types of ovarian (female reproductive organs where eggs are formed), fallopian tube (tube that transports eggs released by the ovaries to the uterus), and peritoneal (layer of tissue that lines the abdomen) cancer in people who have completely responded or partially responded to their first or later chemotherapy treatments. Olaparib is also used to treat certain types of breast cancer that has spread to other parts of the body and has not improved or has worsened after treatment with other therapies. It is also used to treat certain types of early breast cancer in people who have already been treated with other chemotherapy treatments.일반 설명
1-Boc-piperazine is an N-Boc protected piperazine. Crosscoupling of 1-Boc-piperazine with aryl iodides using CuBr/1,1′-bi-2-naphthol (catalyst) and K3PO4 (base) has been reported. 1-Boc-piperazine undergoes Buchwald-Hartwig coupling reactions with aryl halides. 1-Boc-piperazine can be prepared in 80% yield via solvent-free N-Boc protection catalyzed by iodine.tert-Butyl 1-piperazinecarboxylate 준비 용품 및 원자재
원자재
준비 용품
TERT-BUTYL 4-(5-FORMYLPYRID-2-YL)PIPERAZINE-1-CARBOXYLATE
PIPERAZINE-1,4-DICARBOXYLIC ACID TERT-BUTYL ESTER METHYL ESTER
1-(2-Methoxyethyl)piperazine
1-(CYCLOPROPYLMETHYL)PIPERAZINE
tert-Butyl 4-[4-(trifluoromethyl)pyrimidin-2-yl]piperazine-1-carboxylate ,97%
1-Boc-4-(2-formylphenyl)piperazine
1-BOC-4-(4-FORMYLPHENYL)PIPERAZINE
1-(2-PYRAZINYL)-PIPERAZINE
1-(3-Chlorphenyl)piperazine
N-Boc-4-(Cyclopropylmethyl)piperazine
1303512-02-8
4-(2-BROMO-PHENYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
4-(5-AMINOPYRIDIN-2-YL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
4-(2-BROMOETHYL)-1-PIPERAZINECARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTER
4-(3-AMINO-PHENYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
Trimetazidine
tert-Butyl 1-piperazinecarboxylate 공급 업체
글로벌( 841)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Anhui Dexinjia Biopharm Co., Ltd | +86-531-82375818 +86-15064153060 |
alice@jndxj.com | China | 288 | 58 |
Nanjing Sinoda Biological Technology Co., Ltd | +8613401983379 |
sales@njmcn.cn | CHINA | 74 | 58 |
BTC pharm India | +918790379245 |
banny.janga@btcpharm.com | India | 1269 | 58 |
Guangzhou Tosun Pharmaceutical Limited | +8618922120635 |
sales@toref-standards.com | China | 1000 | 58 |
Hebei Mojin Biotechnology Co., Ltd | +8613288715578 |
sales@hbmojin.com | China | 12456 | 58 |
Shaanxi Haibo Biotechnology Co., Ltd | +undefined18602966907 |
qinhe02@xaltbio.com | China | 1000 | 58 |
Anhui Zhongda Biotechnology Co., Ltd | +8619956560829 |
justine@zhongda-biotech.com | China | 300 | 58 |
Anhui Ruihan Technology Co., Ltd | +8617756083858 |
daisy@anhuiruihan.com | China | 994 | 58 |
Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 |
info@fdachem.com | China | 16805 | 58 |
hebei hongtan Biotechnology Co., Ltd | +86-86-1913198-3935 +8617331935328 |
sales03@chemcn.cn | China | 951 | 58 |
tert-Butyl 1-piperazinecarboxylate 관련 검색:
레스메트린 1-아미노에틸피페라진 브푸로페진 피페라진 다이부틸푸탈레이트 부틸 올레인산염 시할로폽부틸 tert-부틸알코올
2-Ethylhexyl ferulate
Piperacillin
N-Carbobenzyloxyglycine
BOC-PIPERAZINE HYDROCHLORIDE
4-(4-fluoro-3-(piperazine-1-carbonyl)benzyl)phthalazin-1(2H)-one
PIPERAZINE DIHYDROCHLORIDE
3-((4-Oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoic acid
1,1,3,3-Tetramethylurea
1-Hydroxybenzotriazole
5-Bromo-2-fluorobenzonitrile