Milrinone
|
|
Milrinone 속성
- 녹는점
- >3000C
- 끓는 점
- 350.9°C (rough estimate)
- 밀도
- 1.1922 (rough estimate)
- 굴절률
- 1.5700 (estimate)
- 저장 조건
- 2-8°C
- 용해도
- DMSO: >10mg/mL
- 물리적 상태
- 가루
- 산도 계수 (pKa)
- 7.21±0.10(Predicted)
- 색상
- 회백색
- 수용성
- DMSO에 용해됩니다. 물에 불용성.
- Merck
- 14,6197
- 안정성
- 안정적인. 강한 산화제와 호환되지 않습니다.
- InChIKey
- FYEJSUDMDUIMKJ-UHFFFAOYSA-N
- CAS 데이터베이스
- 78415-72-2(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | T,T+ | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 23/24/25-26/27/28 | ||
| 안전지침서 | 36/37/39-45-22 | ||
| 유엔번호(UN No.) | UN 2811 6.1/PG 3 | ||
| WGK 독일 | 3 | ||
| RTECS 번호 | DW1762000 | ||
| 위험 등급 | 6.1(b) | ||
| 포장분류 | III | ||
| HS 번호 | 29337900 |
Milrinone C화학적 특성, 용도, 생산
개요
Milrinone, an inhibitor of phosphodiesterase selective for fraction III PDE, exerts a positive inotropic effect on the heart as well as a peripheral vasodilatory effect. Milrinone given intravenously produces significant improvements on cardiac output, pulmonary capillary wedge pressure and vascular resistance without significant effects on the heart rate.화학적 성질
Crystalline Solid용도
It is used (particularly intravenously, as the lactate) for the short-term management of severe heart failure. Milrinone inhibits the action of phosphodiesterase-3 preventing degradation of cAMP. The corresponding increase in cAMP levels leads to increased activation of protein kinase A. It is a selective phosphodiesterase inhibitor with vasodilating and positive inotropic activity.일반 설명
Milrinone, 1,6-dihydro-2-methyl-6-oxo-3,4＇-bipyridine-5-carbonitrile (Primacor), is another dipyridinephosphodiesterase F-III inhibitor that possesses pharmacologicalproperties similar to those of amrinone. The inhibitionof the degradation of cAMP results in an increase in the cardiacmuscle’s force of contraction.생물학적 활성
Potent cAMP phosphodiesterase inhibitor (IC 50 = 56 nM for inhibition of PDE III). Has inotropic and vasodilator effects following oral or intravenous administration in vivo . Also available as part of the Phosphodiesterase Inhibitor Tocriset™ .Milrinone 준비 용품 및 원자재
원자재
Concentrated hydrochloric acid
4-Pyridyl acetone
에틸비닐에테르
γ-피콜린
사이클로헥세인
페닐리튬
클로로포름
디에틸에테르
2-시아노아세트아미드
N,N-디메틸포름아마이드 디메틸 아세탈
메틸이소부틸케톤
말로노니트릴
메틸산 나트륨
4-(dimethylamino)-3-(4-pyridyl)-3-buten-2-one
2-cyano-3-ethoxyacrylamide
2-cyano-3-(dimethylamino)prop-2-enamide
5-Bromo-3-cyano-2-hydroxy-6-methylpyridine
Ethoxymethylenemalononitrile
준비 용품
Milrinone 공급 업체
글로벌( 478)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Hebei Dangtong Import and export Co LTD | +8615632927689 |
admin@hbdangtong.com | China | 990 | 58 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 |
sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21691 | 55 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
fandachem@gmail.com | China | 9346 | 55 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 |
zheyansh@163.com | CHINA | 3620 | 58 |
| career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 |
sales@amoychem.com | China | 6387 | 58 |
| BOC Sciences | +1-631-485-4226 |
inquiry@bocsci.com | United States | 19553 | 58 |
| Beijing Yibai Biotechnology Co., Ltd | 0086-182-6772-3597 |
sales04@yibaibiotech.com | CHINA | 419 | 58 |