CHLORDIAZEPOXIDE HYDROCHLORIDE manufacturers and suppliers

CHLORDIAZEPOXIDE HYDROCHLORIDE suppliers

Properties

Melting point:: 213°

solubility: Soluble in water, sparingly soluble in ethanol (96 per cent).

Stability:: Stable. Incompatible with strong oxidizing agents.

Safety Information

Symbol(GHS): GHS07,GHS08

Signal word: Warning

Hazard statements: H302-H361fd

Precautionary statements: P201-P301+P312+P330-P308+P313

Hazard Codes: Xn

Risk Statements: 22-62-63-68

Safety Statements: 22-36/37

WGK Germany: 3

RTECS: DE9450000

HS Code: 2933910000

Toxicity: LD50 oral in rabbit: 590mg/kg

Use

Chlordiazepoxide hydrochloride, 7-chloro-2-(methylamino)-5-phenyl-3H-1,4-benzodiazepine4-oxide monohydrochloride (Librium), is well absorbedafter oral administration. Peak plasma levels are reachedin 2 to 4 hours. The half-life of chlordiazepoxide is 6 to30 hours. N-demethylation and hydrolysis of the condensedamidino group are rapid and extensive, producing demoxepamas a major metabolite. Demoxepam can undergo fourdifferent metabolic fates. It is converted principally to itsactive metabolite nordazepam, which is also a major activemetabolite of diazepam, clorazepate, and prazepam.Nordazepam, in turn, is converted principally to active oxazepam(marketed separately), which conjugated to the excretedglucuronide. Because of the long half-life of parentdrug and its active metabolites, this drug is long acting andself-tapering. As with diazepam (vide infra), repeated administrationof chlordiazepoxide can result in accumulationof parent drug and its active metabolites, and thus cause excessivesedation.

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