Dyclonine hydrochloride manufacturers and suppliers

Dyclonine hydrochloride suppliers

Properties

Melting point:: 175-176°C

storage temp.: Inert atmosphere,2-8°C

solubility: Soluble in DMSO (20 mg/ml); Water (25 mg/ml)

form: solid

color: White

Water Solubility: Partly soluble in water. Soluble in chloroform, ethanol, acetone and methanol.

Merck: 14,3473

Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 2 months.

InChI: InChI=1S/C18H27NO2.ClH/c1-2-3-15-21-17-9-7-16(8-10-17)18(20)11-14-19-12-5-4-6-13-19;/h7-10H,2-6,11-15H2,1H3;1H

InChIKey: KNZADIMHVBBPOA-UHFFFAOYSA-N

SMILES: C1(C(=O)CCN2CCCCC2)C=CC(OCCCC)=CC=1.Cl

Safety Information

Symbol(GHS): GHS05,GHS06

Signal word: Danger

Hazard statements: H301-H315-H318-H335

Precautionary statements: P261-P264-P280-P301+P310-P302+P352-P305+P351+P338

Hazard Codes: Xn

Risk Statements: 22-37/38-41

Safety Statements: 26-36

RIDADR: 3249

WGK Germany: 3

RTECS: UG8750000

HazardClass: 6.1(b)

PackingGroup: III

HS Code: 2933399090

Use

Dyclonine hydrochloride is the hydrochloride salt of Dyclonine. Dyclonine belongs to a kind of oral anaesthetic. It is contained in the Sucrets as well as some kinds of Cepacol sore throat spray as an active ingredient. Dyclonine takes effect through reversibly binding to the activated sodium channels located on the neuronal membrane. This decreases the permeability of sodium across the neuronal membrane, further increasing the threshold for excitation. Overall, Dyclonine stabilizes the membrane and inhibits depolarization, resulting in the failure of a propagated action potential and further suppressing the subsequent conduction. This causes a transient and reversible anaesthetic effect in a local area of the body.

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