Imipramine hydrochloride suppliers
Imipramine hydrochloride
- CAS:
- 113-52-0
- MF:
- C19H25ClN2
- MW:
- 316.87
Suppliers by country/region
Company Type
Properties
- Melting point:
- 168-1700C
- Flash point:
- 9℃
- storage temp.
- 2-8°C
- solubility
- H2O: 50 mg/mL
- form
- crystalline
- color
- white
- PH
- 4.2~5.2(100g/l,25℃)
- Water Solubility
- Soluble in water
- λmax
- 260nm(lit.)
- Merck
- 14,4920
Safety Information
- Symbol(GHS)
GHS06
- Signal word
- Danger
- Hazard statements
- H300
- Precautionary statements
- P264-P270-P301+P310-P405-P501
- Hazard Codes
- Xn,T,F
- Risk Statements
- 23/25-36/38-36/37/38-22-39/23/24/25-23/24/25-11
- Safety Statements
- 7-16-24-33-45-36-26-36/37
- RIDADR
- UN 1230 3/PG 2
- WGK Germany
- 3
- RTECS
- HO1925000
- TSCA
- Yes
- HS Code
- 2933995800
- Toxicity
- LD50 in mice, rats (mg/kg): 400, 490 orally; 110, 90 i.p. (Tobe)
Use
Imipramine hydrochloride, 5-[3-(dimethylamino)propyl]-10,11-dihydro-5H-dibenz[b,f]azepine monohydrochloride(Tofranil), is the lead compound of the TCAs. It is also a closerelative of the antipsychotic phenothiazines (replace the10–11 bridge with sulfur, and the compound is the antipsychoticagent promazine). It has weaker D2 postsynaptic blockingactivity than promazine and mainly affects amines (5-HT,NE, and DA) via the transporters. As is typical of dimethylaminocompounds, anticholinergic and sedative (central H1block) effects tend to be marked. The compound per se has a tendency toward a high 5-HT-to-NE uptake block ratio andprobably can be called a serotonin transport inhibitor(SERTI). Metabolic inactivation proceeds mainly by oxidativehydroxylation in the 2-position, followed by conjugationwith glucuronic acid of the conjugate. Urinary excretion predominates(about 75%), but some biliary excretion (up to25%) can occur, probably because of the large nonpolargrouping. Oxidative hydroxylation is not as rapid or completeas that of the more nucleophilic ring phenothiazine antipsychotics;consequently, appreciable N-demethylation occurs,with a buildup of norimipramine (or desimipramine).
266 supplier list of "Imipramine hydrochloride"
$1.00/ 1KG
- Product Name:Imipramine hydrochloride
- Products Intro:Purity: 98% | Package: 1KG;1USD
- Company Type: Reagent
- Country/Region: CHINA
- Main Products: Nicotinamide riboside chloride,Curcumin,L(+)-Ascorbic acid,L-Glutamine,Stevioside Basic information
- Product Name:Imipramine HCl
- Company Type: Reagent
- Country/Region: CHINA
- Main Products: Gamma-butyrolactone
$67.00/ 1kg
- Product Name:Imipramine hydrochloride
- Products Intro:Purity: 99%
- Company Type: Trader
- Country/Region: CHINA
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