Lomustine manufacturers and suppliers

Lomustine suppliers

Properties

Melting point:: 88-90

Boiling point:: 63.6°C (rough estimate)

Density: 1.3840 (rough estimate)

refractive index: 1.5790 (estimate)

storage temp.: 2-8°C

solubility: Practically insoluble in water, freely soluble in acetone and in methylene chloride, soluble in ethanol (96 per cent).

pka: 10.88±0.20(Predicted)

color: Light orange to Yellow to Green

Merck: 14,5564

InChIKey: GQYIWUVLTXOXAJ-UHFFFAOYSA-N

Safety Information

Symbol(GHS): GHS06,GHS08

Signal word: Danger

Hazard statements: H301-H350

Precautionary statements: P201-P280-P301+P330+P331+P310-P308+P313

Hazard Codes: T

Risk Statements: 45-25

Safety Statements: 53-45

RIDADR: 3249

WGK Germany: 3

RTECS: YS4900000

HazardClass: 6.1(a)

PackingGroup: II

HS Code: 29299090

Toxicity: LD50 in male mice (mg/kg): 51 orally; 56 i.p.; 61 s.c. (Thompson, Larson)

Use

Lomustine is available in 10-, 40-, and 100-mg capsules fororal administration in the treatment of primary and metastaticbrain cancers and Hodgkin’s lymphoma. This lipophilicagent is well absorbed, widely distributed, and crosses theblood-brain barrier. Lomustine undergoes extensive hepaticmetabolism, which is mediated by CYP3A4 to give severalhydroxylated metabolites, which arise as a result of oxidationof the cyclohexyl ring. Several of these are more activethan the parent compound. Denitrosation and dechlorinationhave also been demonstrated to occur for lomustine as well.The intact drug was not found in plasma when the agent wasadministered orally. Elimination occurs primarily in theurine with an elimination half-life of 16 to 72 hours.Myelosuppression is dose limiting and presents in a mannersimilar to that seen with carmustine. Other toxicities includenausea, vomiting, anorexia, impotence, sterility, amenorrhea,and infertility. Pulmonary and renal toxicity are rarelyseen during standard-dose therapy but increase during highdosetherapy.

You can find Lomustine suppliers, manufacturers, and distributors from countries such as China, United States and the India here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.