PENICILLIC ACID manufacturers and suppliers

PENICILLIC ACID suppliers

Properties

Melting point:: 83-87 °C

Boiling point:: 219.79°C (rough estimate)

Density: 1.1456 (rough estimate)

refractive index: 1.4425 (estimate)

storage temp.: Store at 2-8

solubility: DMSO: >10mg/mL

form: solid

pka: 3.90±0.33(Predicted)

color: Needles from pet ether or rhombic orhexagonal plates

Merck: 13,7163

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H302

Precautionary statements: P271-P260

Hazard Codes: Xn,T

Risk Statements: 36/37/38-20/21/22-22

Safety Statements: 37/39-26-24/25

RIDADR: 2811

RTECS: MM2625000

HazardClass: 6.1(b)

PackingGroup: III

HS Code: 29189900

Toxicity: LD50 i.p. in mice: 90.00 mg/kg (Chan et al.)

Use

Gram negative bacteria utilize N-acylated homoserine lactones to coordinate expression of virulence in response to the density of the surrounding bacterial population in a process termed quorum sensing. By interfering with this communication and thereby disrupting virulence expression, quorum sensing inhibitors are emerging as an alternative to the conventional ways of fighting bacterial infections. Penicillic acid is a mycotoxin produced from Penicillium species identified in molds on corn and other grains. At 80 μM, penicillic acid inhibits bacterial quorum sensing communication in P. aeruginosa by selectively repressing various virulence factor and other quorum sensing-regulated genes. It has been shown to inhibit Fas-mediated apoptosis at 100-200 μM by targeting caspase-8 activity in Burkitt’s lymphoma Raji cells.

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