T0901317 suppliers
T0901317
- CAS:
- 293754-55-9
- MF:
- C17H12F9NO3S
- MW:
- 481.33
Suppliers by country/region
Company Type
Properties
- Melting point:
- 116-118°C
- Boiling point:
- 470.5±55.0 °C(Predicted)
- Density
- 1.550±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- DMSO (Slightly), Methanol (Slightly)
- pka
- 9.00±0.15(Predicted)
- form
- Light beige solid
- color
- Off-White
- InChIKey
- SGIWFELWJPNFDH-UHFFFAOYSA-N
Safety Information
- WGK Germany
- 3
Use
The Liver X Receptors (LXRα and LXRβ) are nuclear hormone receptors whose native ligands are oxysterols, such as 22(R)-hydroxycholesterol. The LXRs regulate the oxysterol-induced expression of cholesterol 7α-hydroxylase, the rate limiting enzyme of classic bile acid synthesis. T0901317 is a potent and selective agonist for both LXRα and LXRβ, with an EC50 of about 50 nM. T0901317 acting through LXR and in concert with its RXR heterodimerization partner induces the expression of the ABCA1 reverse cholesterol transporter. This acts to increase the efflux of cholesterol from enterocytes and thus inhibit the overall absorption of cholesterol.
102 supplier list of "T0901317"
- Product Name:T0901317
- Products Intro:Purity: 95% | Package: 100mg;1g;500g | CustNote: Topule Company operates with integrity and has its own laboratory, which supports packaging and customization. Payment will be made after the product has passed third-party testing
- Company Type: Trader
- Country/Region: CHINA
- Main Products: Pharmaceutical intermediates,raw materials,small molecule inhibitors,food additives,Biochemical reagents
- Product Name:T0901317
- Products Intro:Purity: >=98% | Package: $29.9/5mg;$49.9/10mg;$75.9/25mg;$95.9/50mg;$149.9/100mg;Bulk package | CustNote: 98%
- Company Type: Trader
- Country/Region: UNITED STATES
- Main Products: Chemicals and BioChemicals,Materials Science,ligands acting on targets,Proteins,Antibodies
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