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ChemicalBook >> CAS DataBase List >> Palonosetron Hydrochloride

Palonosetron Hydrochloride

Palonosetron Hydrochloride price.
  • $15 - $1450
  • Product name: Palonosetron Hydrochloride
  • CAS: 135729-62-3
  • MF: C19H25ClN2O
  • MW: 332.87
  • EINECS:680-630-6
  • MDL Number:MFCD07370072
  • Synonyms:PALONOSETRON HYDROCHLORIDE;(3aS)-2-(3S)-1-Azabicyclo[2.2.2]oct-3-yl-2,3,3a,4,5,6-hexahydro-1H-benz[de]isoquinolin-1-one Hydrochloride;Onicit;RS-25259-197;(3aS)-2-(3S)-1-Azabicyclo[2.2.2]oct-3-yl-2,3,3a,4,5,6-hexahydro-1H-benz[de]isoquinolin-1-one monohydrochloride;(S,S)-Palonosetron Hydrochloride;(S,S)-Palonosetron HCl;(3aS)-2-[(S)-1-Azabicyclo[2.2.2]oct-3-yl]-2,3,3a,4,5,6-hexahydro-1-oxo-1H-benz[de]isoquinoline hydrochloride
39 prices
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  • AHH
  • AK Scientific
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  • ApexBio Technology
  • Arctom
  • AvaChem
  • Biosynth Carbosynth
  • Cayman Chemical
  • Chem-Impex
  • ChemScene
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Package
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  • 1g
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  • 10mM(in 1mL DMSO)
  • ManufacturerAHH
  • Product numberMT-20625
  • Product descriptionPalonosetron Hydrochloride 98%
  • Packaging1g
  • Price$538
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberH672
  • Product descriptionPalonosetron Hydrochloride
  • Packaging200mg
  • Price$150
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberH672
  • Product descriptionPalonosetron Hydrochloride
  • Packaging1g
  • Price$605
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA195751
  • Product descriptionPalonosetron Hydrochloride 98+%
  • Packaging10mg
  • Price$15
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA195751
  • Product descriptionPalonosetron Hydrochloride 98+%
  • Packaging50mg
  • Price$25
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA195751
  • Product descriptionPalonosetron Hydrochloride 98+%
  • Packaging100mg
  • Price$32
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA195751
  • Product descriptionPalonosetron Hydrochloride 98+%
  • Packaging250mg
  • Price$48
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA195751
  • Product descriptionPalonosetron Hydrochloride 98+%
  • Packaging1g
  • Price$134
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA195751
  • Product descriptionPalonosetron Hydrochloride 98+%
  • Packaging5g
  • Price$405
  • Updated2021-12-16
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  • ManufacturerApexBio Technology
  • Product numberB2229
  • Product descriptionPalonosetronHCl
  • Packaging25mg
  • Price$40
  • Updated2021-12-16
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  • ManufacturerApexBio Technology
  • Product numberB2229
  • Product descriptionPalonosetronHCl
  • Packaging10mM(in 1mL DMSO)
  • Price$50
  • Updated2021-12-16
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  • ManufacturerApexBio Technology
  • Product numberB2229
  • Product descriptionPalonosetronHCl
  • Packaging200mg
  • Price$150
  • Updated2021-12-16
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  • ManufacturerArctom
  • Product numberAS472946
  • Product descriptionPalonosetron Hydrochloride ≥98%
  • Packaging250mg
  • Price$48
  • Updated2021-12-16
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  • ManufacturerArctom
  • Product numberAS472946
  • Product descriptionPalonosetron Hydrochloride ≥98%
  • Packaging1g
  • Price$133
  • Updated2021-12-16
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  • ManufacturerArctom
  • Product numberCFN90009
  • Product descriptionPalonosetron Hydrochloride ≥98%
  • Packaging20mg
  • Price$218
  • Updated2021-12-16
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  • ManufacturerAvaChem
  • Product number2167
  • Product descriptionPalonosetron Hydrochloride
  • Packaging10mg
  • Price$45
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AHH MT-20625 Palonosetron Hydrochloride 98% 1g $538 2021-12-16 Buy
AK Scientific H672 Palonosetron Hydrochloride 200mg $150 2021-12-16 Buy
AK Scientific H672 Palonosetron Hydrochloride 1g $605 2021-12-16 Buy
Ambeed A195751 Palonosetron Hydrochloride 98+% 10mg $15 2021-12-16 Buy
Ambeed A195751 Palonosetron Hydrochloride 98+% 50mg $25 2021-12-16 Buy
Ambeed A195751 Palonosetron Hydrochloride 98+% 100mg $32 2021-12-16 Buy
Ambeed A195751 Palonosetron Hydrochloride 98+% 250mg $48 2021-12-16 Buy
Ambeed A195751 Palonosetron Hydrochloride 98+% 1g $134 2021-12-16 Buy
Ambeed A195751 Palonosetron Hydrochloride 98+% 5g $405 2021-12-16 Buy
ApexBio Technology B2229 PalonosetronHCl 25mg $40 2021-12-16 Buy
ApexBio Technology B2229 PalonosetronHCl 10mM(in 1mL DMSO) $50 2021-12-16 Buy
ApexBio Technology B2229 PalonosetronHCl 200mg $150 2021-12-16 Buy
Arctom AS472946 Palonosetron Hydrochloride ≥98% 250mg $48 2021-12-16 Buy
Arctom AS472946 Palonosetron Hydrochloride ≥98% 1g $133 2021-12-16 Buy
Arctom CFN90009 Palonosetron Hydrochloride ≥98% 20mg $218 2021-12-16 Buy
AvaChem 2167 Palonosetron Hydrochloride 10mg $45 2021-12-16 Buy

Properties

Melting point :>290°C
alpha :D25 -94.1° (c = 0.4 in water)
storage temp. :Inert atmosphere,Store in freezer, under -20°C
solubility :Methanol (Slightly, Heated), Water (Slightly)
form :Solid
color :White to Off-White
Merck :14,6997
InChI :InChI=1/C19H24N2O.ClH/c22-19-16-6-2-4-14-3-1-5-15(18(14)16)11-21(19)17-12-20-9-7-13(17)8-10-20;/h2,4,6,13,15,17H,1,3,5,7-12H2;1H/t15-,17-;/s3
InChIKey :OLDRWYVIKMSFFB-HYCRUXCXNA-N
SMILES :N1(C[C@@]2([H])CCCC3=CC=CC(=C32)C1=O)[C@H]1[C@]2([H])CCN(CC2)C1.Cl |&1:2,15,16,r|
CAS DataBase Reference :135729-62-3(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H312 Harmful in contact with skin Acute toxicity,dermal Category 4 Warning GHS hazard pictograms P280,P302+P352, P312, P322, P363,P501
H332 Harmful if inhaled Acute toxicity,inhalation Category 4 Warning GHS hazard pictograms P261, P271, P304+P340, P312
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P312 Call a POISON CENTER or doctor/physician if you feel unwell.
P322 Specific measures (see …on this label).
P330 Rinse mouth.
P363 Wash contaminated clothing before reuse.
P501 Dispose of contents/container to..…

Description

Palonosetron is a potent, selective antagonist of the serotonin (5-HT) receptor 5-HT3 (pKi = 10.4 in rat cortex) that minimally effects a wide range of other neuronal receptors. It is orally bioavailable and potently inhibits emesis induced by chemotherapeutic drugs, like cisplatin , but not by apomorphine , which acts by dopamine receptor antagonism. Palonosetron is remarkable for its long duration of action, related to its high receptor-binding affinity and long half-life. It is effective in managing chemotherapy-induced nausea and vomiting.

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