Telithromycin

Use

Telithromycin (Ketek) is an orally bioavailable macrolide.The antibiotic is semisynthetic. Telithromycin is classifiedas a ketolide, and it differs chemically from the macrolidegroup of antibacterials by the lack of α-L-cladinose at 3-position of the erythronolide A ring, resulting in a 3-ketofunction. It is further characterized by imidazolyl andpyridyl rings inked to the macrolide nucleus through a butylchain. The mechanism of action of telithromycin is the sameas that of the macrolide class.Telithromycin causes a blockade of protein synthesis bybinding to domains II and V of 23S rRNA of the 50S ribosomalsubunit. Because telithromycin binds at domain II,activity against Gram-positive cocci is retained in the presenceof resistance mediated by methylases that alter thedomain V binding site. The antibiotic is also believed to inhibitthe assembly of ribosomes. Resistance to telithromycinoccurs because of riboprotein mutations.

Telithromycin manufacturers

• Telithromycin
• 
• US $10.50 / KG
• 2023-03-06
• CAS:191114-48-4
• Min. Order: 1KG
• Purity: 99
• Supply Ability: 1 ton

• Telithromycin
• 
• US $0.00 / G
• 2023-02-09
• CAS:191114-48-4
• Min. Order: 1G
• Purity: 98%min
• Supply Ability: 30kg/month

• Telithromycin
• 
• US $10.00 / Kg/Bag
• 2021-11-04
• CAS:191114-48-4
• Min. Order: 1Kg/Bag
• Purity: 99%
• Supply Ability: 20 Tons