| Company Name: |
Riedel-de Haen AG
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| Tel: |
800 558-9160 |
| Email: |
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| Products Intro: |
Cas:67-97-0
ProductName:Colecalciferol
Brand:Sigma-Aldrich | Product Number:BP787 | Purity:BritishPharmacopoeia(BP)ReferenceStandard
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| Company Name: |
Guangzhou Younan Technology Co., Ltd
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| Tel: |
020-020-82000279 18988968278 |
| Email: |
YN_research@163.com |
| Products Intro: |
Cas:67-97-0
ProductName:Colecalciferol;Cholecalciferol
Purity: >98% HPLC | Package: 5Mg;10Mg ;25mg;50mg;100Mg;250Mg ;500Mg ;1g
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| | Colecalciferol Basic information |
| Product Name: | Colecalciferol | | Synonyms: | RACUMIN D;OLEOVITAMIN D3;ANTI-RACHITIC VITAMIN;CHOLECALCIFEROLUM;22-Dihydroergocalciferol;Cyclohexanol, 4-methylene-3-[(2E)-2-[(1R,3aS,7aR)-octahydro-7a-methyl-1-[(1R,4S)-1,4,5-trimethylhexyl]-4H-inden-4-ylidene]ethylidene]-, (1S,3Z)-;(3S,5Z,7E)-9,10-Secoergosta-5,7,10-trien-3-ol;VITAMINE D4 | | CAS: | 511-28-4 | | MF: | C28H46O | | MW: | 398.66 | | EINECS: | 208-127-5 | | Product Categories: | Steroids;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals | | Mol File: | 511-28-4.mol |  |
| | Colecalciferol Chemical Properties |
| Melting point | 83-86 °C(lit.) | | alpha | D18 +89.3° (c = 0.47 in acetone) | | Boiling point | 504.9±29.0 °C(Predicted) | | density | 0.96 | | storage temp. | 2-8°C | | solubility | Soluble in Chloroform | | form | Powder | | pka | 14.74±0.20(Predicted) | | Stability: | Hygroscopic, Temperature Sensitive | | CAS DataBase Reference | 511-28-4(CAS DataBase Reference) |
| | Colecalciferol Usage And Synthesis |
| Description | Derived from cholesterol, vitamin D is biosynthesized from its prohormone cholecalciferol (D3), the product of
solar ultraviolet irradiation of 7-dehydrocholesterol in the skin.
In 1966, it was first recognized that vitamin
D must undergo activation via two oxidative metabolic steps. The first oxidation to
25-hydroxycholecalciferol (25(OH)D3: calcifediol; Calderol) occurs in the endoplasmic reticulum of the liver and
is catalyzed by vitamin D 25-hydroxylase. This activation step is not
regulated by plasma calcium concentrations. The major circulating form (10–80 μg/mL) is 25(OH)D3, which also
is the primary storage form of vitamin D. | | Chemical Properties | Pale Yellow Oil | | Uses | Vitamin D4 is the active analogue of Vitamin D. | | Definition | ChEBI: Vitamin D4 is it is present in mushrooms. It has a role as a fungal metabolite. It is a vitamin D and a seco-ergostane. | | Biological Functions | Sterol-specific cytoplasmic receptor proteins (vitamin D receptor) mediate the biological action of vitamin D.
The active hormone is transported from the cytoplasm to the nucleus via the vitamin D receptor, and as a result
of the interaction of the hormone with target genes, a variety of proteins are produced that stimulate the
transport of calcium in each of the target tissues
Active vitamin D works in concert with PTH to enhance active
intestinal absorption of calcium, to stimulate bone resorption, and to prohibit renal excretion of calcium. If
serum calcium or 1,25-calcitriol concentrations are elevated, then vitamin D 24-hydroxylase (in renal
mitochondria) is activated to oxidize 25(OH)D3 to inactive 24,25-dihydroxy-cholecalciferol and to further oxidize
active vitamin D to the inactive 1,24,25-trihydroxylated derivative. Both the 1,24,25-trihydroxylated and the
24,25-dihydroxylated products have been found to suppress PT H secretion as well. The biosynthesis of vitamin D is tightly regulated based on the serum concentrations of calcium, phosphate, PTH, and active vitamin D. |
| | Colecalciferol Preparation Products And Raw materials |
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