| Company Name: |
3B Pharmachem (Wuhan) International Co.,Ltd.
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| Tel: |
821-50328103-801 18930552037 |
| Email: |
3bsc@sina.com |
| Products Intro: |
Product Name:CP 80633;5-[3-[(1S,2S,4R)-Bicyclo[2.2.1]hept-2-yloxy]-4-Methoxyphenyl]tetrahydro-2(1H)-pyriMidinone
CAS:135637-46-6
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
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| Company Name: |
EMMX Biotechnology LLC
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| Tel: |
888-539-0666 |
| Email: |
info@emmx.com |
| Products Intro: |
Product Name:CP 80633
CAS:135637-46-6
Purity:98% HPLC Package:5mg;10mg;25mg;50mg;100mg;250mg;500mg;1g
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| Company Name: |
Shanghai Han-Xiang Chemical Co., Ltd.
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| Tel: |
15971444841 |
| Email: |
amber@biochempartner.com |
| Products Intro: |
Product Name:Atizoram
CAS:135637-46-6
Purity:98% HPLC LCMS Package:100G;1KG
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| | 5-[4-methoxy-3-[(2S)-norbornan-2-yl]oxy-phenyl]-1,3-diazinan-2-one Basic information |
| Product Name: | 5-[4-methoxy-3-[(2S)-norbornan-2-yl]oxy-phenyl]-1,3-diazinan-2-one | | Synonyms: | 5-[4-methoxy-3-[(2S)-norbornan-2-yl]oxy-phenyl]-1,3-diazinan-2-one;5-[3-[(1S,2S,4R)-Bicyclo[2.2.1]hept-2-yloxy]-4-methoxyphenyl]tetrahydro-2(1H)-pyrimidinone;CP 80633;AtizoraM;2(1H)-Pyrimidinone, 5-[3-[(1S,2S,4R)-bicyclo[2.2.1]hept-2-yloxy]-4-methoxyphenyl]tetrahydro-;Atizoram, CP-80633 | | CAS: | 135637-46-6 | | MF: | C18H24N2O3 | | MW: | 316.39 | | EINECS: | | | Product Categories: | | | Mol File: | 135637-46-6.mol | ![5-[4-methoxy-3-[(2S)-norbornan-2-yl]oxy-phenyl]-1,3-diazinan-2-one Structure](CAS/GIF/135637-46-6.gif) |
| | 5-[4-methoxy-3-[(2S)-norbornan-2-yl]oxy-phenyl]-1,3-diazinan-2-one Chemical Properties |
| Boiling point | 543.0±50.0 °C(Predicted) | | density | 1.178±0.06 g/cm3(Predicted) | | storage temp. | Store at +4°C | | solubility | DMF: 3 mg/ml; DMF:PBS (pH 7) (1:10): 0.1 mg/ml; DMSO: 2 mg/ml | | form | A crystalline solid | | pka | 14.05±0.40(Predicted) |
| | 5-[4-methoxy-3-[(2S)-norbornan-2-yl]oxy-phenyl]-1,3-diazinan-2-one Usage And Synthesis |
| Uses | CP 80633 is a selective inhibitor of phosphodiesterase type 4. | | Uses | Phosphodiesterases (PDE) enzymatically convert the cyclic nucleotide second messengers cAMP and cGMP to 5’-AMP and 5’-GMP, respectively, thus terminating signal transduction. The cAMP-specific PDE4 isoforms may be particularly important in certain respiratory and neurological diseases. CP 80,633 is a selective inhibitor of PDE4 (IC50 = 1.27 μM for PDE4 versus. >100 μM for PDE1, PDE2, PDE3, and PDE5). It potentiates PGE1-dependent increases in cAMP levels in eosinophils, monocytes, and T-cells, inhibits eosinophil superoxide production (IC50 < 0.6 μM), and blocks LPS-induced TNF-α release from monocytes (IC50 = 0.22 μM). CP 80,633 (1 mg/kg) significantly reduces antigen-induced airway inflammation in atopic guinea pigs, monkeys, and mice.[Cayman Chemical] | | Definition | ChEBI: 2(1h)-pyrimidinone, 5-[3-[(1s,2s,4r)-bicyclo[2.2.1]hept-2-yloxy]-4-methoxyphenyl]tetrahydro- is a monoterpenoid. | | Biological Activity | Selective inhibitor of phosphodiesterase type 4 (IC 50 values are 1.9, > 100, > 100, > 100 and > 100 μ M for human lung PDE4, lung PDE1, lung PDE2, heart PDE3 and platelet PDE-V respectively) that displays no significant PDE4 isozyme selectivity. Inhibits hydrolysis of cAMP in isolated human peripheral blood monocytes, eosinophils and T cells.? Displays anti-inflammatory and bronchodilatory effects in vivo . |
| | 5-[4-methoxy-3-[(2S)-norbornan-2-yl]oxy-phenyl]-1,3-diazinan-2-one Preparation Products And Raw materials |
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