| Company Name: |
J & K SCIENTIFIC LTD.
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| Tel: |
010-82848833 400-666-7788 |
| Email: |
jkinfo@jkchemical.com |
| Products Intro: |
Product Name:NSC 109555
CAS:15427-93-7
Package:100Mg,10Mg,50Mg
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| Company Name: |
3B Pharmachem (Wuhan) International Co.,Ltd.
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| Tel: |
821-50328103-801 18930552037 |
| Email: |
3bsc@sina.com |
| Products Intro: |
Product Name:NSC 109555 ditosylate;4,4'-diacetyldiphenylureabis(guanylhydrazone)ditosylate
CAS:15427-93-7
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
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| Company Name: |
Sigma-Aldrich
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| Tel: |
021-61415566 800-8193336 |
| Email: |
orderCN@merckgroup.com |
| Products Intro: |
Product Name:NSC109555
CAS:15427-93-7
Purity:>=98% (HPLC) Package:25MG Remarks:SML0781-25MG
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| | 4,4'-diacetyldiphenylureabis(guanylhydrazone)ditosylate Basic information |
| Product Name: | 4,4'-diacetyldiphenylureabis(guanylhydrazone)ditosylate | | Synonyms: | NSC 109555;2,2′-[Carbonylbis(imino-4,1-phenyleneethylidyne)]-bis-Hydrazinecarboximidamide methanesulfonate (1:2);NSC109555 Dimesylate;4,4'-diacetyldiphenylureabis(guanylhydrazone)ditosylate;NSC 109555 ditosylate;DDUG dimethanesulfonate;DDUG diMS | | CAS: | 15427-93-7 | | MF: | C20H28N10O4S | | MW: | 504.56592 | | EINECS: | | | Product Categories: | | | Mol File: | 15427-93-7.mol |  |
| | 4,4'-diacetyldiphenylureabis(guanylhydrazone)ditosylate Chemical Properties |
| storage temp. | 2-8°C | | solubility | H2O: soluble5mg/mL, clear (warmed) | | form | powder | | color | white to beige |
| | 4,4'-diacetyldiphenylureabis(guanylhydrazone)ditosylate Usage And Synthesis |
| Uses | NSC 109555 is an inhibitor of checkpoint kinase 2 (Chk2), a serine/threonine kinase involved in the ATM-Chk2 checkpoint pathway. Drugs that target Chk2 in combination with DNA-damaging agents can be beneficial in cancer therapy. Studies in mice, rats, rabbits, dogs, and monkeys have shown that NSC 109555 displays toxic effects. A singe injection of the drug at a concentration of 12.5-25 mg/kg caused acute paralysis leading to apnea and death. | | Biochem/physiol Actions | NSC109555 is a selective inhibitor of Chk2 (IC50 = 310 nM). The compound is reversible and competitive for ATP, and displays little or no activity against other related kinases, including Chk1, at concentrations up to 10 μM. |
| | 4,4'-diacetyldiphenylureabis(guanylhydrazone)ditosylate Preparation Products And Raw materials |
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