| Company Name: |
EMMX Biotechnology LLC
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| Tel: |
888-539-0666 |
| Email: |
info@emmx.com |
| Products Intro: |
Product Name:NBI 35965 hydrochloride
CAS:603151-83-3
Purity:98% HPLC Package:5mg;10mg;25mg;50mg;100mg;250mg;500mg;1g
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| Company Name: |
Pharmacodia (Beijing) Co.,Ltd
|
| Tel: |
+86-400-851-9921 |
| Email: |
sales@pharmacodia.com |
| Products Intro: |
Product Name:NBI-35965 Mesylate
CAS:603151-83-3
Package:10Mg-100g
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| | NBI 35965 hydrochloride Basic information |
| | NBI 35965 hydrochloride Chemical Properties |
| Melting point | 167 °C | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO > 10 mM | | form | Powder |
| | NBI 35965 hydrochloride Usage And Synthesis |
| Uses | NBI 35965 Mesylate is a selective corticotropin-releasing factor (CRF1) receptor antagonist involved in stress response. | | Uses | Corticotropin-releasing hormone, also known as corticotropin-releasing factor (CRF) or corticoliberin, is a peptide hormone and neurotransmitter involved in the stress response. It is secreted from the hypothalamus and is the major regulator of pituitary corticotropin-release and consequent glucocorticoid secretion. NBI 35965 is a selective CRF receptor 1 (CRF1) antagonist with a Ki value of 4 nM. It does not inhibit CRF2 (Ki = >10,000 nM). NBI 35965 inhibits cAMP accumulation and adrenocorticotropic hormone (ACTH) production in vitro (pIC50s = 7.1 and 6.9, respectively) and reduces CRF- and stress-induced ACTH production in vivo. In animal models of stress, NBI 35965 administration produces anxiolytic effects.[Cayman Chemical] | | Uses | NBI 35965 Hydrochloride is a potent and selective corticotropin-releasing factor 1 (CRF1) antagonist. |
| | NBI 35965 hydrochloride Preparation Products And Raw materials |
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