1-(2-THIAZOLYLAZO)-2-NAPHTHOL manufacturers
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| | 1-(2-THIAZOLYLAZO)-2-NAPHTHOL Basic information |
| | 1-(2-THIAZOLYLAZO)-2-NAPHTHOL Chemical Properties |
| Melting point | 138-139 °C | | Boiling point | 464.8±47.0 °C(Predicted) | | density | 1.40 | | storage temp. | 2-8°C | | solubility | methanol: 10 mg/mL, clear | | pka | 8.71±0.50(Predicted) | | form | solid | | color | Red or orange | | BRN | 223783 | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. | | CAS DataBase Reference | 1147-56-4(CAS DataBase Reference) | | EPA Substance Registry System | 2-Naphthalenol, 1-(2-thiazolylazo)- (1147-56-4) |
| Risk Statements | 36/37/38 | | Safety Statements | 22-24/25 | | WGK Germany | 3 | | TSCA | Yes | | HS Code | 2927.00.5000 |
| | 1-(2-THIAZOLYLAZO)-2-NAPHTHOL Usage And Synthesis |
| Description | ERGi-USU (1147-56-4) selectively inhibits the growth of ERG-positive VCaP prostate cancer cells, COLO320 colon cancer cells, KG-1 and MOLT-4 leukemia cells with minimal effect on ERG-negative cells or normal prostate or endothelial cells (IC50 = 169 nM for cell growth and 315 nM for ERG protein in VCaP cells). It selectively inhibits the kinase RIOK2 (Kd = 200 nM) causing disruption of ribosomal biogenesis and ribosomal stress. | | Uses | 1-(2-Thiazolylazo)-2-naphthol is a high affinity Rio Kinase 2 (RIOK2) inhibitor (Kd = 200 nM). Exhibits >6-fold selectivity for RIOK2 over a panel of 456 kinases. Inhibits ERG protein and potently inhibits growth of ERG-positive VCaP prostate cancer cells in vitro (IC50 = 169 nM) but not ERG-negative cell lines. Also inhibits growth of VCaP xenografts in mice. | | storage | Store at +4°C | | References | 1) Mohamed et al. (2018), Identification of a Small Molecule That Selectively Inhibits ERG-Positive Cancer Cell Growth; Cancer Res. 78 3659 |
| | 1-(2-THIAZOLYLAZO)-2-NAPHTHOL Preparation Products And Raw materials |
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