| Company Name: |
Hangzhou Peptidego Biotech Co.,Ltd.
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| Tel: |
0571-87213919 |
| Email: |
eric@peptidego.com |
| Products Intro: |
Product Name:Z-Val-Ala-Asp(OEt)-CH2-DCB
CAS:161511-45-1
Purity:95% or 98% HPLC Package:1mg；5mg；10mg；50mg；100mg,1g or according to customer's detail requirement.
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| Company Name: |
Wuxi Helen Biotechnology Co., Ltd.,
|
| Tel: |
0510-85629785 18013409632 |
| Email: |
sales@reading-chemicals.com |
| Products Intro: |
Product Name:Z-Val-Ala-Asp(OEt)-CH2-DCB
CAS:161511-45-1
Purity:>=95% Package:10mg;25mg;50mg;100mg;200mg;500mg
|
| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
4008200310 |
| Email: |
marketing@tsbiochem.com |
| Products Intro: |
Product Name:SDZ 224-015;SDZ 224015,SDZ 224 015
CAS:161511-45-1
Purity:98% Package:25 mg
|
| Company Name: |
Hangzhou Sinoda Pharmaceutical Technology Co. LTD
|
| Tel: |
0571-87213919 17306812703 |
| Email: |
3007955328@qq.com |
| Products Intro: |
Product Name:Z-Val-Ala-Asp(OEt)-CH2-DCB
CAS:161511-45-1
Purity:95% or 98% HPLC Package:1mg；5mg；10mg；50mg；100mg,1g or according to customer's detail requirement.
|
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| | L-Alaninamide,N-[(phenylmethoxy)carbonyl]-L-valyl-N-[(1S)-3-[(2,6-dichlorobenzoyl)oxy]-1-(2-ethoxy-2-oxoethyl)-2-oxopropyl]-(9CI) Basic information |
| | L-Alaninamide,N-[(phenylmethoxy)carbonyl]-L-valyl-N-[(1S)-3-[(2,6-dichlorobenzoyl)oxy]-1-(2-ethoxy-2-oxoethyl)-2-oxopropyl]-(9CI) Chemical Properties |
| Boiling point | 861.9±65.0 °C(Predicted) | | density | 1.299±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | pka | 11.05±0.46(Predicted) |
| | L-Alaninamide,N-[(phenylmethoxy)carbonyl]-L-valyl-N-[(1S)-3-[(2,6-dichlorobenzoyl)oxy]-1-(2-ethoxy-2-oxoethyl)-2-oxopropyl]-(9CI) Usage And Synthesis |
| Biological Activity | SDZ 224-015 is an orally active inhibitor of the interleukin-1 beta (IL-1β) converting enzyme and caspase-1. SDZ 224-015 possesses anti-COVID-19 activity, targeting Mpro (IC50 of 30 nM)[1][2].
SDZ 224-015 (0.3-300 μg/kg) potently reduces carrageenin-induced paw oedema[2].SDZ 224-015 (0.2-5 mg/kg, p.o.) displays analgesic activity in the Randall-Selitto yeast-inflamed paw pressure test, significant at a dose of 1 mg/kg[2]. | | References | [1]. Martin A Redhead, et al. Bispecific repurposed medicines targeting the viral and immunological arms of COVID-19. Sci Rep. 2021 Jun 24;11(1):13208. [2]. P R Elford, et al. Reduction of inflammation and pyrexia in the rat by oral administration of SDZ 224-015, an inhibitor of the interleukin-1 beta converting enzyme. Br J Pharmacol. 1995 Jun;115(4):601-6. |
| | L-Alaninamide,N-[(phenylmethoxy)carbonyl]-L-valyl-N-[(1S)-3-[(2,6-dichlorobenzoyl)oxy]-1-(2-ethoxy-2-oxoethyl)-2-oxopropyl]-(9CI) Preparation Products And Raw materials |
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