3-溴丙酮酸
中文名称 | 3-溴丙酮酸 |
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中文同义词 | 溴丙酮酸,97%;3-溴丙酮酸;3-溴-2-氧代丙酸3-溴丙酮酸;3-溴庚酸;3-溴-2-氧代丙酸;3-溴丙酮酸97%;溴丙酮酸;3-溴代丙酮酸 |
英文名称 | 3-Bromopyruvic acid |
英文同义词 | 3-Bromopyruvic acid ,97%;2-Oxo-3-bromopropionic acid;Hexokinase II Inhibitor II, 3-BP;3-bromo-2-oxo-propanoicaci;Bromopyruvic acid, 3-Bromo-2-oxopropionic acid;NSC 11731;NSC 62343;Propanoic acid,3-broMo-2-oxo- |
CAS号 | 1113-59-3 |
分子式 | C3H3BrO3 |
分子量 | 166.96 |
EINECS号 | 214-206-5 |
相关类别 | 农药中间体;杀菌剂中间体;通用试剂;羧酸;有机砌块;有机酸;羰基化合物;Aliphatics;Carboxylic Acids;Organic acids;Carboxylic Acids;苯并咪唑类杀菌剂;Piperidines;农药原料;材料中间体及助剂;有机化工;有机化学;细胞生物学试剂 |
Mol文件 | 1113-59-3.mol |
结构式 |
3-溴丙酮酸 性质
熔点 | 77-82 °C |
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沸点 | 223.4±23.0 °C(Predicted) |
密度 | 1.7314 (rough estimate) |
折射率 | 1.4650 (estimate) |
储存条件 | 2-8°C |
溶解度 | 水中的溶解度:1g/10mL,透明,无色 |
形态 | 白色结晶固体 |
酸度系数(pKa) | 1.84±0.54(Predicted) |
颜色 | 白色到近乎白色 |
水溶解性 | Soluble in water, dimethyl sulfoxide, ethyl acetate and water. |
BRN | 1746786 |
InChIKey | PRRZDZJYSJLDBS-UHFFFAOYSA-N |
CAS 数据库 | 1113-59-3(CAS DataBase Reference) |
EPA化学物质信息 | Propanoic acid, 3-bromo-2-oxo- (1113-59-3) |
3-Bromopyruvate enhances TRAIL-induced apoptosis in breast cancer cells.
3-Bromopyruvate (Bromopyruvic acid), a hexokinase II inhibitor, can induce apoptosis in hepatocellular carcinoma cells by inducing endoplasmic reticulum (ER) stress.
3-Bromopyruvate inhibits ATP generation and upregulates the expression of DR5. 3-Bromopyruvate upregulates CHOP, GRP78 and the phosphorylation of AMPK and augments TRAIL-induced Bax and caspase-3 levels.
Cell Viability Assay
Cell Line: | MCF-7 and MDA-MB-231 cells |
Concentration: | 40, 80, 160 or 320 µM |
Incubation Time: | 24 hours |
Result: | 3-Bromopyruvate (80 and 160 µmol/l) and TRAIL (400 ng/ml) significantly inhibited cell viability. |
3-Bromopyruvate (8 mg/kg; i.p.; every 4 days for 28 days) shows a synergistic antitumor effect in MCF-7 cell xenografts in nude mice.
Animal Model: | Female nude mice (BALB/c; 4-5-weeks old and 18-20 g) |
Dosage: | 8 mg/kg |
Administration: | I.p.; every 4 days for 28 days |
Result: | Showed antitumor efficacy in tumor xenografts. |
安全信息
危险品标志 | C |
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危险类别码 | 34-20/21/22 |
安全说明 | 26-36/37/39-45-27 |
危险品运输编号 | UN 3261 8/PG 2 |
WGK Germany | 3 |
RTECS号 | UZ0840000 |
F | 19-21 |
Hazard Note | Corrosive |
TSCA | Yes |
危险等级 | 8 |
包装类别 | II |
海关编码 | 29183000 |
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