|
|
| | 10,11-DIHYDRO-10-HYDROXYCARBAZEPINE Basic information |
| Product Name: | 10,11-DIHYDRO-10-HYDROXYCARBAZEPINE | | Synonyms: | 5-Carbamoyl-10,11-dihydro-5H-dibenzo[b,f]azepine-10-ol;6-hydroxy-5,6-dihydrobenzo[b][1]benzazepine-11-carboxamide;10,11-Dihydro-10-hydroxy-5H-dibenz(Z)[b,f]azepin-5-carboxamide;10-hydroxy-10,11-dihydro-5H-dibenzo[b,f]azepine-5-carboxaMide;10,11-Dihydro-10-hydroxy;(±)-10-Hydroxy-10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxaMide;5H-Dibenz[b,f]azepine-5-carboxaMide,10,11-dihydro-10-hydroxy-;10,11-Dihydro-10-Hydroxycarbamazepine solution | | CAS: | 29331-92-8 | | MF: | C15H14N2O2 | | MW: | 254.28 | | EINECS: | | | Product Categories: | Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;Isotope Labeled Compounds | | Mol File: | 29331-92-8.mol |  |
| | 10,11-DIHYDRO-10-HYDROXYCARBAZEPINE Chemical Properties |
| Melting point | 186-189°C | | Boiling point | 431.3±55.0 °C(Predicted) | | density | 1.336 | | Fp | 2℃ | | storage temp. | -20°C | | solubility | Soluble to 100 mM in DMSO and to 50 mM in ethanol | | pka | 13.75±0.20(Predicted) | | BRN | 1540211 | | InChIKey | BMPDWHIDQYTSHX-UHFFFAOYSA-N | | CAS DataBase Reference | 29331-92-8 |
| | 10,11-DIHYDRO-10-HYDROXYCARBAZEPINE Usage And Synthesis |
| Chemical Properties | White Solid | | Uses | 10,11-dihydro-10-hydroxy Carbamazepinee is the active metabolite of oxcarbazepine . Oxcarbazepine is rapidly and almost completely converted to 10,11-dihydro-10-hydroxycarbamazepine, which then demonstrates anticonvulsant efficacy by modulating several ion channels and receptors. ?10,11-dihydro-10-hydroxy Carbamazepine is reported to inhibit both voltage-gated Na+ and Ca2+ channels, to potentiate voltage-gated K+ channels, to antagonize adenosine A1 receptors, to increase dopaminergic transmission, and to inhibit glutamate release. | | Uses | A labelled metabolite of Oxcarbazepine | | Uses | A metabolite of Oxcarbazepine | | Definition | ChEBI: A dibenzoazepine that is 5H-dibenzo[b,f]azepine, reduced across the C-10,11 positions and carrying a carbamoyl substituent at the azepine nitrogen and a hydroxy function at C-10. A voltage-gated sodium channel b
ocker with anticonvulsant and mood-stabilizing effects, it is related to oxcarbazepine and is an active metabolite of oxcarbazepine. | | storage | Store at RT |
| | 10,11-DIHYDRO-10-HYDROXYCARBAZEPINE Preparation Products And Raw materials |
|