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| | S-(2-BORONOETHYL)-L-CYSTEINE HYDROCHLORIDE Basic information |
| Product Name: | S-(2-BORONOETHYL)-L-CYSTEINE HYDROCHLORIDE | | Synonyms: | BEC HCl;S-(2-BORONOETHYL)-L-CYSTEINE HYDROCHLORIDE;BEC HCl, 98%, a slow-binding and competitive Arginase II inhibitor;BEC hydrochloride - S-(2-Boronoethyl)-L-cysteine hydrochloride;Reaxys ID: 25974550;(R)-2-amino-3-((2-boronoethyl)thio)propanoic acid hydrochloride;Inhibitor,NF-κB,hyperresponsiveness,metaplasia,inhibit,Arginase,BEC,BEC hydrochloride,Arginase-II,inflammation,CCL20;Methsuximide Impurity 1(Normesuximide) | | CAS: | 222638-67-7 | | MF: | C5H13BClNO4S | | MW: | 229.48 | | EINECS: | | | Product Categories: | | | Mol File: | 222638-67-7.mol |  |
| | S-(2-BORONOETHYL)-L-CYSTEINE HYDROCHLORIDE Chemical Properties |
| storage temp. | Inert atmosphere,Store in freezer, under -20°C | | solubility | PBS (pH 7.2): 10 mg/ml | | form | A crystalline solid |
| | S-(2-BORONOETHYL)-L-CYSTEINE HYDROCHLORIDE Usage And Synthesis |
| Description | BEC is a potent slow-binding competitive inhibitor of recombinant rat liver arginase I with Ki values of 0.4 and 0.6 μM from kinetic analyses. It is also a potent inhibitor of human arginase II with Ki values of 310 and 30 nM at pH 7.5 and 9.5, respectively. It does not inhibit murine iNOS at concentrations up to 1 mM. BEC significantly enhances nitric oxide-dependent relaxation of human penile corpus cavernosum smooth muscle in vitro when used at concentrations ranging from 0.1 to 1 mM. | | Uses | BEC Hydrochloride is Arginase II inhibitor. For the biological study of the inhibition of arginase II, it prevented nitrate tolerance in human umbilical vein endothelial cell and in mouse aorta. |
| | S-(2-BORONOETHYL)-L-CYSTEINE HYDROCHLORIDE Preparation Products And Raw materials |
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