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| | Misoprostol Acid Basic information |
| | Misoprostol Acid Chemical Properties |
| Boiling point | 538.3±50.0 °C(Predicted) | | density | 1.118±0.06 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | Chloroform | | pka | 4.77±0.10(Predicted) | | form | Yellow viscous oil. | | color | Pale Yellow | | Stability: | Temperature Sensitive |
| | Misoprostol Acid Usage And Synthesis |
| Description | Misoprostol is a prostaglandin E1 analog with agonist activity mediated by EP2, EP3, and EP4 receptors. It has been shown to inhibit the formation of gastric lesions in rats (ED50 = 0.31 μg/kg), inhibit superoxide generation in human neutrophils (EC50 = 0.35 μM), and relax fetal rabbit ductus arteriosus (EC50 = 0.36 nM) in a concentration dependent manner. Misoprostol is commonly used in clinical medicine for the prevention of peptic ulcer disease. It has also been used in conjunction with mifepristone (RU-486; ) for the oral induction of first trimester abortion. Misoprostol contains a C-1 methyl ester and is readily absorbed and rapidly hydrolyzed in humans to the active free acid. | | Chemical Properties | Pale Yellow Gel | | Uses | Misoprostol Acid is a prostaglandin E1 analog with agonist activity mediated by EP2, EP3, and EP4 receptors. It has been shown to inhibit the formation of gastric lesions in rats (ED50 = 0.31 μg/kg), inhibit superoxide generation in human neutrophils (EC50 = 0.35 μM), and relax fetal rabbit ductus arteriosus (EC50 = 0.36 nM) in a concentration dependent manner. Misoprostol is commonly used in clinical medicine for the prevention of peptic ulcer disease. It has also been used in conjunction with mifepristone (RU-486; ) for the oral induction of first trimester abortion. Misoprostol contains a C-1 methyl ester and is readily absorbed and rapidly hydrolyzed in humans to the active free acid. | | Uses | A cytoprotective prostaglandin PGE1 analogue. | | Uses | A metabolite of Misoprostol. Cytoprotective PGE1 analog that prevents NSAID-induced gastric ulceration | | Biochem/physiol Actions | Misoprostol is a synthetic prostaglandin E1 (PGE1) analogue use to prevent non steroidal anti inflammatory drug-induced (NSAID) gastric ulcers; as a labor inducing and postpartum hemorrhage treatment agent. |
| | Misoprostol Acid Preparation Products And Raw materials |
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