| Company Name: |
J & K SCIENTIFIC LTD.
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| Tel: |
010-82848833 400-666-7788 |
| Email: |
jkinfo@jkchemical.com |
| Products Intro: |
Product Name:PeriMethazine
CAS:13093-88-4
Package:2.5g,250Mg
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| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Email: |
marketing@energy-chemical.com |
| Products Intro: |
Product Name:Perimethazine
CAS:13093-88-4
Purity:NULL Package:2.5g;250mg Remarks:NULL
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| | perimetazine Basic information |
| Product Name: | perimetazine | | Synonyms: | perimetazine;AN 1317;AN-1317;Leptryl;RP 9159;RP-9159;1-(3-(2-Methoxy-10H-phenothiazin-10-yl)-2-methylpropyl)piperidin-4-ol;1-[3-(2-methoxyphenothiazin-10-yl)-2-methylpropyl]piperidin-4-ol | | CAS: | 13093-88-4 | | MF: | C22H28N2O2S | | MW: | 384.541 | | EINECS: | 2360093 | | Product Categories: | | | Mol File: | 13093-88-4.mol |  |
| | perimetazine Chemical Properties |
| Melting point | 137-138° | | Boiling point | 569.1±50.0 °C(Predicted) | | density | 1.0944 (rough estimate) | | refractive index | 1.6000 (estimate) | | pka | 14.87±0.20(Predicted) |
| | perimetazine Usage And Synthesis |
| Originator | Leptryl ,Roger Bellon, France,1970 | | Uses | Perimethazine, is a novel Antipsychotic drug. It has shown to cause sedation, hypothermia, muscle relaxation, and other signs of central depression in rabbits. | | Definition | ChEBI: Perimetazine is a member of phenothiazines. | | Manufacturing Process | A solution of 3-methoxy-10-(3-chloro-2-methylpropyl)phenthiazine (9.65 grams) and 4-hydroxypiperidine (6.1 grams) in xylene (10 cc) is heated under reflux for 5 hours. After cooling the mixture is diluted with ether (60 cc) and the basic compounds are extracted by agitation with water (30 cc) and 4 N hydrochloric acid (20 cc). The aqueous acid phase is made alkaline with 4 N sodium hydroxide solution (23 cc) and the liberated base is extracted with ether. The ethereal solution is washed with water (60 cc) and dried over sodium sulfate. Finally the solvent is distilled off on a water-bath.
The solid residue obtained is recrystallized from a mixture (15:85) of benzene and cyclohexane and there is obtained 3-rnethoxy-10-[2-methyl-3-(4hydroxy-1-piperidyl)-propyl]-phenthiazine (5.7 grams) as a white crystalline powder, MP 137°-138°C. | | Therapeutic Function | Tranquilizer |
| | perimetazine Preparation Products And Raw materials |
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