GALANIN (2-11) PORCINE, RAT manufacturers
- Galanin (2-11)
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- $1.00 / 1KG
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2019-12-23
- CAS:367518-31-8
- Min. Order: 1g
- Purity: Min98% HPLC
- Supply Ability: g/kg /ton
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| | GALANIN (2-11) PORCINE, RAT Basic information |
| | GALANIN (2-11) PORCINE, RAT Chemical Properties |
| Boiling point | 1595.4±65.0 °C(Predicted) | | density | 1.291±0.06 g/cm3(Predicted) | | storage temp. | −20°C | | solubility | Soluble to 1 mg/ml in 20% formic acid | | pka | 9.82±0.15(Predicted) | | form | lyophilized powder |
| | GALANIN (2-11) PORCINE, RAT Usage And Synthesis |
| Biological Activity | binding ic50: 1.76 nm for rgalr2; 879 nm for hgalr1galanin is a 29-aa neuropeptide with a complex role in pain processing. galanin receptor subtypes are present in dorsal root ganglia and spinal cord with a differential distribution. three galanin receptors, galr1, galr2 and galr3, have been identified and cloned. ar-m1896 is a specific galanin r2 (galr2) agonist. | | in vitro | additional removal of the glycine residue in position 1 resulted in ar-m1896 with almost unchanged galr2 affinity and functional activity, and 500-fold selectivity for galr2-rs over galr1-rs. this compound represents a truly galr2-selective galanin analog and, thus, could be used as a pharmacological tool to differentiate between these two receptors [1]. | | in vivo | in normal rats mechanical and cold allodynia of the hindpaw are induced by intrathecal infusion of low-dose galanin. the same effect is seen with equimolar doses of ar-m1896 or ar-m961 (an agonist both at galr1 and galr2 receptors). in allodynic bennett model rats, the mechanical threshold dose-dependently increased after intrathecal injection of a high ar-m961dose, whereas no effect was observed in the control or ar-m1896 group. no effect of either compounds was observed in nonallodynic bennett model rats [1]. | | references | [1] liu hx, brumovsky p, schmidt r, brown w, payza k, hodzic l, pou c, godbout c, hökfelt t. receptor subtype-specific pronociceptive and analgesic actions of galanin in the spinal cord: selective actions via galr1 and galr2 receptors. proc natl acad sci u s a. 2001 aug 14;98(17):9960-4. |
| | GALANIN (2-11) PORCINE, RAT Preparation Products And Raw materials |
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