| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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| Tel: |
18818260767 |
| Email: |
sales@chemegen.com |
| Products Intro: |
Product Name:KOdiA-PC
CAS:439904-33-3
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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| Company Name: |
MedBioPharmaceutical Technology Inc
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| Tel: |
021-69568360 18916172912 |
| Email: |
order@med-bio.cn |
| Products Intro: |
Product Name:KOdiA-PC
CAS:439904-33-3
Purity:98% Package:1mg (solution); 500ug (solution); 5mg (solution); 10mg (solution) Remarks:Medbio
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| Company Name: |
Shanghai Yifei Biotechnology Co. , Ltd.
|
| Tel: |
021-65675885 18964387627 |
| Email: |
customer_service@efebio.com |
| Products Intro: |
Product Name:KOdiA-PC Exclusive
CAS:439904-33-3
Purity:98% Package:500μg;1mg;5mg
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| | KOdiA-PC Basic information |
| Product Name: | KOdiA-PC | | Synonyms: | KOdiA-PC;KOdiA-PC Exclusive;PEZXEQJZQAVYCZ-NLMPBQEBSA-N | | CAS: | 439904-33-3 | | MF: | C32H58NO11P | | MW: | 663.79 | | EINECS: | | | Product Categories: | | | Mol File: | 439904-33-3.mol |  |
| | KOdiA-PC Chemical Properties |
| storage temp. | Store at -80°C, protect from light | | solubility | DMF: .5 mg/ml; DMSO: .5 mg/ml; Ethanol: 30 mg/ml; PBS (pH7.2): 5 mg/ml |
| | KOdiA-PC Usage And Synthesis |
| Description | Oxidized low-density lipoprotien (oxLDL) particles contain low molecular weight species which are cytotoxic and pro-atherogenic.1 Many of these substances were recently isolated and purified from oxLDL, and identified as phosphatidylcholine species containing a fragmented, oxidized short-chain fatty acid remnant at the sn-2 position.2 1-(Palmitoyl)-2-(5-keto-6-octene-dioyl) phosphatidylcholine, or KOdiA-PC, is one of the most potent CD36 ligands among the oxLDL species.3 KOdiA-PC confers CD36 scavenger receptor binding affinity to LDL at a frequency of only 2 to 3 KOdiA-PC molecules/LDL particle, and may be one of the more important structural determinants of oxLDL. | | Definition | ChEBI: PKODiA-PC is a 1,2-diacyl-sn-glycero-3-phosphocholine. | | References | 1. Podrez, E.A., Febbraio, M., Sheibani, N., et al. Macrophage scavenger receptor CD36 is the major receptor for LDL modified by monocyte-generated reactive nitrogen species J. Clin. Invest. 105(8),1095-1108(2000).
2. Podrez, E.A., Poliakov, E., Shen, Z., et al. A novel family of atherogenic oxidized phospholipids promotes macrophage foam cell formation via the scavenger receptor CD36 and is enriched in atherosclerotic lesions J. Biol. Chem. 277(41),38517-38523(2002).
3. Podrez, E.A., Poliakov, E., Shen, Z., et al. Identification of a novel family of oxidized phospholipids that serve as ligands for the macrophage scavenger receptor CD36 J. Biol. Chem. 277(41),38503-38516(2002). |
| | KOdiA-PC Preparation Products And Raw materials |
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