|
|
| | (OC-6-44)-Tricarbonylchloro(glycinato)ruthenium Basic information |
| Product Name: | (OC-6-44)-Tricarbonylchloro(glycinato)ruthenium | | Synonyms: | (OC-6-44)-Tricarbonylchloro(glycinato)ruthenium;CORM-3;Ruthenium, tricarbonylchloro(glycinato-κN,κO)-, (OC-6-44)-;Carbon monoxide releasing molecule 3;Tricarbonylchloro(glycinato)ruthenium (II);Tricarbonylchloro(glycinato)ruthenium;inhibit,Inhibitor,Nuclear factor-kappaB,Nuclear factor-κB,CORM 3,CORM-3,NF-κB,NOD-like Receptor (NLR);(OC-6-44)-Tricarbonylchloro(glycinato-κN,κO)ruthenium | | CAS: | 475473-26-8 | | MF: | C5H3ClNO5Ru | | MW: | 293.6 | | EINECS: | | | Product Categories: | Inhibitors | | Mol File: | 475473-26-8.mol |  |
| | (OC-6-44)-Tricarbonylchloro(glycinato)ruthenium Chemical Properties |
| storage temp. | -20°C | | solubility | H2O: soluble20mg/mL, clear | | form | powder | | color | light yellow to dark yellow | | Water Solubility | Soluble to 100 mM in water |
| | (OC-6-44)-Tricarbonylchloro(glycinato)ruthenium Usage And Synthesis |
| Uses | CORM-3 (carbon monoxide (CO) releasing molecule-3) has been used to study its effect on NLRP3 (leucine-rich-repeat-containing receptor, pyrin-domain-containing 3) inflammasome activation via glycolysis in macrophages and also on hyperglycemia-induced IL-1β (interleukin-1 β) production. It has also been used to study its protective function against H2O2-induced apoptosis using primary rabbit lens epithelial cells. | | Biochem/physiol Actions | CORM-3 is a water-soluble carbon monoxide (CO) releasing molecule that can be used to study the effects of CO on cellular systems. Carbon monoxide (CO), produced during the degradation of heme by the enzyme heme oxygenase, has recently been found to be an important gaseous signaling mediator in mammalian cells CORM-3 has been shown to have anti-inflammatory and cardioprotective activity. | | storage | Store at -20°C |
| | (OC-6-44)-Tricarbonylchloro(glycinato)ruthenium Preparation Products And Raw materials |
|