| | PHENCYCLIDINE Basic information |
| Product Name: | PHENCYCLIDINE | | Synonyms: | Methanol(test Phencyclidine(PCP),1.0mg/mL);PCP (Phencyclidine) solution
;1-(1-PHENYLCYCLOHEXYL)PIPERIDINE;Pcp (phencyclidine);Phencyclidine (pcp);Phencylidine;Piperidine, 1-(1-phenylcyclohexyl)-;1-(1-Phenylcyclohexyl)piperidine solution, PCP solution | | CAS: | 77-10-1 | | MF: | C17H25N | | MW: | 243.39 | | EINECS: | | | Product Categories: | | | Mol File: | 77-10-1.mol |  |
| | PHENCYCLIDINE Chemical Properties |
| Melting point | 46.5℃ | | Boiling point | bp1.0 135-137° | | density | 0.9762 (rough estimate) | | refractive index | 1.5000 (estimate) | | Fp | 11 °C | | storage temp. | −20°C | | pka | pKa 8.5 (Uncertain) | | color | Colorless crystals | | EPA Substance Registry System | Piperidine, 1-(1-phenylcyclohexyl)- (77-10-1) |
| | PHENCYCLIDINE Usage And Synthesis |
| Uses | Anesthetic. | | Definition | ChEBI: A member of the class of piperidines that is piperidine in which the nitrogen is substituted with a 1-phenylcyclohexyl group. Formerly used as an anaesthetic agent, it exhibits both hallucinogenic and neurotoxic effects. | | Brand name | Sernylan (Parke-Davis). | | General Description | Phencyclidine was introduced as a dissociative anestheticfor animals. Its close structural relative ketamine is still soused and may be used in humans. In humans,PCP produces a sense of intoxication, hallucinogenic experiencesnot unlike those produced by the anticholinergic hallucinogens,and often, amnesia.
The drug affects many systems, including those of NE,DA, and 5-HT. It has been proposed that PCP (and certainother psychotomimetics) produces a unique pattern of activationof ventral tegumental area dopaminergic neurons.Itblocks glutaminergic N-methyl-D-aspartate receptors.Thisaction is the basis for many of its CNS effects. PCP itself appearsto be the active agent. The psychotic state produced bythis drug is also cited as a better model than amphetaminepsychosis for the psychotic state of schizophrenia. | | Pharmacology | PCP acts as a biocide through its ability
to uncouple mitochondrial oxidative phosphorylation. | | Safety Profile | Poison by intraperitoneal route. Experimental reproductive effects. Caution: This is a controlled substance (depressant) listed in the U.S. Code of Federal Regulations, Title 21 Part 1308.12 (1985). The ethylamine, pyrrolidine and thiophene analogs are l | | Metabolic pathway | When mice and rats are administered phencyclidine
intraperitoneally, several hydroxylated metabolites are
identified in the urine. A new metabolite, 1-phenyl-1-
(1-piperidinyl-3-ol)cyclohexane, is identified in the urine
and liver microsomal preparations. | | Metabolism | Pentachlorophenolwas metabolized in rats
by conjugation with glucuronic acid and eliminated as
the glucuronide. P450 catalyzed oxidative dechlorination
also occurred to form tetrachlorohydroquinone, and this
was conjugated to form a monoglucuronide representing
27% of the dose administered. Other metabolites
have been reported, including isomeric tetrachlorophenols,
tetrachlorocatechol and tetrachlororesorcinol. Trace
amounts of benzoquinones were also noted.
Metabolites in female rats were tetrachloromonophenols,
diphenols, and hydroquinones. | | Toxicity evaluation | The toxicology has been addressed in a
recent risk assessment (119). Acutely, pentachlorophenol
was reported to have LD50 values in the rat of 12 mg/kg
(inhalation) and 146 mg/kg (M)–175 mg/kg (F) by oral
gavage. More detailed studies of the toxicology of pentachlorophenol
have been compromised by the toxicity of
impurities present in most of the earlier samples used
in the evaluation process. |
| | PHENCYCLIDINE Preparation Products And Raw materials |
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