| (1S,2S)-(+)-Pseudoephedrine hydrochloride Basic information |
Product Name: | (1S,2S)-(+)-Pseudoephedrine hydrochloride | Synonyms: | (+)-PSI-EPHEDRINE HYDROCHLORIDE;PSI-EPHEDRINE HYDROCHLORIDE;PSEUDOEPHEDRINE HCL, (+)-1S,2S-;(+)-PSEUDOEPHEDRINE HYDROCHLORIDE;a)]-;alpha-(1-(methylamino)ethyl)-,hydrochloride,(s-(r*,r*))-benzenemethano;benzenemethanol,alpha-[1-(methylamino)ethyl]-,hydrochloride,[s-(theta,thet;hydrochloride,l-(+)-pseudoephedrin | CAS: | 345-78-8 | MF: | C10H16ClNO | MW: | 201.69 | EINECS: | 206-462-1 | Product Categories: | Pharmaceutical Raw Materials;Amines;Aromatics;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals;API's | Mol File: | 345-78-8.mol | |
| (1S,2S)-(+)-Pseudoephedrine hydrochloride Chemical Properties |
| (1S,2S)-(+)-Pseudoephedrine hydrochloride Usage And Synthesis |
Chemical Properties | white powder | Uses | Non-selective adrenergic agonist; decongestant (nasal).
Controlled precursor. | Definition | ChEBI: A hydrochloride that is the monohydrochloride salt of pseudoephedrine. | Brand name | Efidac (ALZA); Novafed (Sanofi Aventis);
Sudafed (GlaxoSmithKline); Sudafed (Warner Lambert). | Contact allergens | This sympathomimetic a-adrenergic agonist is found
in plants of the genus Ephedra (Ephedraceae) and is
systemically used as a nasal decongestant. It can induce
drug skin reactions such as acute generalized exanthematic
pustulosis or generalized eczema. | Clinical Use | Nasal decongestant | Drug interactions | Potentially hazardous interactions with other drugs
Adrenergic neurone blockers: antagonise hypotensive
effect of adrenergic neurone blockers.
Anaesthetics: increased risk of ventricular
arrhythmias with isoflurane.
Antibacterials: risk of hypertensive crisis with
linezolid.
Antidepressants: risk of hypertensive crisis with
MAOIs and moclobemide.
Dopaminergics: avoid concomitant use with
selegiline and rasagiline. | Metabolism | A small amount of pseudoephedrine is hepatically
metabolised by N-demethylation.
It is excreted largely unchanged in the urine with small
amounts of its hepatic metabolite. | Purification Methods | 1S,2S-Pseudoephedrine hydrochloride [345-78-8] M 210.7, m 181-182o, 185-188o, [ + 6 1o (c 1 H2O). Crystallise the salt from EtOH. [Beilstein 13 IV 1878.] |
| (1S,2S)-(+)-Pseudoephedrine hydrochloride Preparation Products And Raw materials |
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