| Company Name: |
3B Pharmachem (Wuhan) International Co.,Ltd.
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821-50328103-801 18930552037 |
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3bsc@sina.com |
| Products Intro: |
Product Name:SCH 202676 hydrobroMide;N-(2,3-Diphenyl-1,2,4-thiadiazol-5(2H)-ylidene)MethanaMinehydrobroMide
CAS:70375-43-8
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
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| Company Name: |
EMMX Biotechnology LLC
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| Tel: |
888-539-0666 |
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info@emmx.com |
| Products Intro: |
Product Name:SCH 202676 hydrobromide
CAS:70375-43-8
Purity:98% HPLC Package:5mg;10mg;25mg;50mg;100mg;250mg;500mg;1g
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| | N-(2,3-DIPHENYL-1,2,4-THIADIAZOL-5(2H)-YLIDENE)METHANAMINE HYDROBROMIDE Basic information |
| Product Name: | N-(2,3-DIPHENYL-1,2,4-THIADIAZOL-5(2H)-YLIDENE)METHANAMINE HYDROBROMIDE | | Synonyms: | N-(2,3-DIPHENYL-1,2,4-THIADIAZOL-5(2H)-YLIDENE)METHANAMINE HYDROBROMIDE;SCH-202676;SCH 202676 HYDROBROMIDE;AURORA KA-7903;N-(2,3-DIPHENYL-1,2,4-THIADIAZOL-5-(2H)-YLIDENE)METHANAMINE, HBR;Methanamine, N-(2,3-diphenyl-1,2,4-thiadiazol-5(2H)-ylidene)-;SCH 202676 HBr;SCH202676 HBr | | CAS: | 70375-43-8 | | MF: | C15H13N3S | | MW: | 267.35 | | EINECS: | | | Product Categories: | G-Protein | | Mol File: | 70375-43-8.mol |  |
| | N-(2,3-DIPHENYL-1,2,4-THIADIAZOL-5(2H)-YLIDENE)METHANAMINE HYDROBROMIDE Chemical Properties |
| Melting point | 240.0-240.8 °C(lit.) | | storage temp. | Desiccate at +4°C | | solubility | DMSO: 40 mg/mL | | form | Yellow solid. | | color | Beige | | Stability: | Stable for 1 year from date of purchase as supplied. Protect from exposure to moisture. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 |
| | N-(2,3-DIPHENYL-1,2,4-THIADIAZOL-5(2H)-YLIDENE)METHANAMINE HYDROBROMIDE Usage And Synthesis |
| Description | SCH-202676 (70375-43-8) is a reversible inhibitor of both agonist and antagonist binding to G protein-coupled receptors (GPCRs).1 IC50‘s = 0.1-1.7 μM for nine GPCRs.1 Modification of GPCRs is accomplished via sulfhydryl modification.2,3 | | Uses | SCH-202676 hydrobromide is a modulator that inhibits binding to G protein-coupled receptors. | | Biological Activity | Sulphydryl-reactive compound that inhibits agonist and antagonist binding to G-protein-coupled receptors. Inhibits a variety of GPCRs including adenosine, opioid, muscarinic, adrenergic and dopaminergic receptors (IC 50 values are 0.1-1.8 μ M). | | References | 1) Fawzi et al. (2001), SCH-202676: an allosteric modulator of both agonist and antagonist binding to G protein-coupled receptors; Mol.Pharmacol. 59 30
2) Lewandowicz et al. (2006), The allosteric modulator SCH-202676 disrupts G protein-coupled receptor function via sulphydryl-sensitive mechanisms; Br. J. Pharmacol. 147 422
3) Goblyos et al. (2005), Synthesis and biological evaluation of a new series of 2,3,5-substituted[1,2,4]-thiadiazoles as modulators of adenosine A1 receptors and their molecular mechanism of action; J. Med. Chem., 48 1145 |
| | N-(2,3-DIPHENYL-1,2,4-THIADIAZOL-5(2H)-YLIDENE)METHANAMINE HYDROBROMIDE Preparation Products And Raw materials |
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