| Company Name: |
J & K SCIENTIFIC LTD.
|
| Tel: |
010-82848833 400-666-7788 |
| Email: |
jkinfo@jkchemical.com |
| Products Intro: |
Product Name:Dichlorisone
CAS:7008-26-6
Package:250Mg,25Mg
|
| Company Name: |
Chemsky (shanghai) International Co.,Ltd
|
| Tel: |
021-50135380 |
| Email: |
shchemsky@sina.com |
| Products Intro: |
Product Name:Dichlorisone ;(11β)-9,11-Dichloro-17,21-dihydroxypregna-1,4-diene-3,20-dione; 9,11β-Dichloro-17,21-dihydroxypregna-1,4-diene-3,20-dione; 9α,11β-Dichloro-17α,21-dihydroxypregna-1,4-diene-3,20-dione
CAS:7008-26-6
Purity:98+% Package:1Mg;5Mg;10Mg;50Mg;100Mg;500Mg
|
| Company Name: |
Shaanxi Dideu Newmaterial Co., Ltd.
|
| Tel: |
029-63373950 15353716720 |
| Email: |
1052@dideu.com |
| Products Intro: |
Product Name:(8S,9R,10S,11S,13S,14S,17R)-9,11-dichloro-17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
CAS:7008-26-6
Purity:98% Package:25kg
|
| Company Name: |
CLEARSYNTH LABS LTD.
|
| Tel: |
+91-22-45045900 |
| Email: |
sales@clearsynth.com |
| Products Intro: |
Product Name:Dichlorisone
CAS:7008-26-6
|
|
| | dichlorisone Basic information |
| Product Name: | dichlorisone | | Synonyms: | 9,11β-Dichloro-17,21-dihydroxypregna-1,4-diene-3,20-dione;Diloderm;Disoderm;(11β)-9,11-Dichloro-17,21-dihydroxypregna-1,4-diene-3,20-dione;Pregna-1,4-diene-3,20-dione, 9,11-dichloro-17,21-dihydroxy-, (11β)-;(8S,9R,10S,11S,13S,14S,17R)-9,11-dichloro-17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one | | CAS: | 7008-26-6 | | MF: | C21H26Cl2O4 | | MW: | 413.34 | | EINECS: | 2302838 | | Product Categories: | Intermediates & Fine Chemicals;Pharmaceuticals;Steroids | | Mol File: | 7008-26-6.mol |  |
| | dichlorisone Chemical Properties |
| Melting point | 238-241 °C (decomp)(Solv: acetone (67-64-1)) | | alpha | D20 +134° (pyridine) | | Boiling point | 586.4±50.0 °C(Predicted) | | density | 1.37±0.1 g/cm3(Predicted) | | solubility | Chloroform (Slightly, Heated), DMSO (Slightly, Heated), Pyridine (Slightly, Sonicated) | | form | Solid | | pka | 11.99±0.70(Predicted) | | color | White to Off-White |
| | dichlorisone Usage And Synthesis |
| Originator | Diloderm ,Schering,US,1960 | | Uses | Dichlorisone is a 9α,11β-dichloro corticoid. Dichlorisone has anti-antiinflammatory potency. Dichlorisone could be modifed to be used as glucocorticoid receptor agonists as well as a P-glycoprotein inhibitor. | | Manufacturing Process | A solution of 1.0 g of 1,4,9(11)-pregnatriene-17α,21-diol-3,20-dione-21-
acetate and 5.0 g of lithium chloride in 40 ml of glacial acetic acid is treated
with 0.410 g of N-chlorosuccinimide, followed by 0.104 g of anhydrous
hydrogen chloride dissolved in 2.5 ml of tetrahydrofuran. The reaction mixture
is stirred for 2 hours and poured into ice water. The crude product is filtered
and washed with water to give 1.12 g of solid material, which is recrystallized
from acetone-hexane to give substantially pure 9α,11β-dichloro-1,4-
pregnadiene-17α,21-diol-3,20-dione-21-acetate; MP 246°C to 253°C (dec.). | | Therapeutic Function | Antipruritic, Antihistaminic, Appetite stimulant |
| | dichlorisone Preparation Products And Raw materials |
|