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Tadalafil

Cialis is tadalafil, is an orally administrated drug developed by the pharmaceutical company Eli Lily for treatment of male erectile dysfunction disease. It belongs to the second generation of phosphodiesterase type 5 inhibitors. Study has shown that compared with sildenafil, the onset rate of Cialis is very rapid with about 15 ~ 20 min for onset and with long-term effects up to 36h.
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CAS:171596-29-5
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Tadalafil Basic information
Indications and uses Clinical Research Side effects Warnings and precautions
Product Name:Tadalafil
Synonyms:TADALAFIL;CIALIS;IC 351;(6r,12ar)-6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-methyl-pyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione;TADALAFIL(CIALIS);Taladafil (cialis);Cialis/taladafil;Cialis(IC351)
CAS:171596-29-5
MF:C22H19N3O4
MW:389.4
EINECS:200-835-2
Product Categories:Active Pharmaceutical Ingredients;Cnbio;Erectile Dysfunction;Pyridines ,Halogenated Heterocycles;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;API's;Steroid and Hormone;Inhibitor;API;Tadalafil;NUCYNTA
Mol File:171596-29-5.mol
Tadalafil Structure
Tadalafil Chemical Properties
Melting point 298-300°C
alpha D20 +71.0°
Fp 2℃
storage temp. Hygroscopic, -20?C Freezer, Under Inert Atmosphere
solubility DMSO: soluble20mg/mL, clear
color white to beige
InChIKeyWOXKDUGGOYFFRN-IIBYNOLFSA-N
CAS DataBase Reference171596-29-5(CAS DataBase Reference)
Safety Information
Hazard Codes F,Xn
Risk Statements 11-20/21/22-36
Safety Statements 16-36/37
RIDADR UN 1648 3 / PGII
RTECS UQ4431050
Hazardous Substances Data171596-29-5(Hazardous Substances Data)
MSDS Information
Tadalafil Usage And Synthesis
Indications and usesCialis (or Tadalafil) was developed by American pharmaceutical company Lilly. It is used to treat erectile dysfunction and belongs to a second generation of PDE5 inhibitors. Studies show that Cialis works very quickly, taking effect in around 15-20 minutes, and has a prolonged effect that can last for up to 36 hours. T1/2 is 17.5h.
Clinical ResearchIn a study of 348 cases of mild to severe erectile dysfunction, patients were randomly given 20mg of Cialis or a placebo. Results showed that in comparison to the placebo group, patients who took Cialis experienced improved intercourse success in the 24-36 hours following medication, with many patients achieving successful sexual intercourse twice in 36 hours. Side effect rate and severity were also no different from those of the placebo group. Over 5% of patients in the Cialis group experienced headaches and indigestion.
Side effectsNo severe negative reactions. No perceived facial flushing or sight abnormalities following medication. Rare cases of headache and indigestion.
Warnings and precautionsPatients currently taking nitrates, experiencing angina pectoris, suffering from heart disease, patients who have unregulated hypertension or hypotension, or patients who have had a stroke in the past 6 months should not take Cialis.
DescriptionTadalafil (market name “Cialis” or “Adcirca”) is a kind of PDE5 inhibitor used for the treatment of erectile dysfunction, benign prostatic hypertrophy and pulmonary arterial hypertension. The effect of Tadalafil is relaxing the blood vessels muscles and increasing the blood flow into the corpus cavernosum. The mechanism of action of tadalafil is through inhibiting the activity of the cGMP specific phosphodiesterase type 5 (PDE5). PDE5 degrades cGMP in the corpus cavernosum located around the penis. Therefore, tadalafi leads to the increased concentration of cGMP which further causes the smooth muscle relaxation and increased blood flow into the corpus cavernosum. Some clinical studies also implied that tadalafil could improve endothelia function in men with increased cardiovascular risk and lower the urinary tract symptoms secondary to benign prostatic hyperplasia.
Chemical PropertiesWhite to Off-White Cyrstalline Solid
UsesUsed for the treatment of erectile dysfunction. A phosphodiesterase 5 inhibitor
Usesanalgesic, norepinephrine uptake blocker, mu-opiod receptor agonist
DefinitionChEBI: A pyrazinopyridoindole that is 2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione substituted at position 2 by a methyl group and at position 6 by a 1,3-benzodioxol-5-yl group (the 6R,12aR
Referenceshttps://www.drugs.com/tadalafil.html
https://www.drugbank.ca/drugs/DB00820
Roehrborn, C. G., et al. "Tadalafil administered once daily for lower urinary tract symptoms secondary to benign prostatic hyperplasia: a dose finding study." Journal of Urology 180.4(2008):1228.
Rosano, Giuseppe M. C., et al. "Chronic Treatment with Tadalafil Improves Endothelial Function in Men with Increased Cardiovascular Risk." European Urology 47.2(2005):214-222.
Tadalafil Preparation Products And Raw materials
Tag:Tadalafil(171596-29-5) Related Product Information
2-Methylpyrazine Sodium hydrosulfide Oils, vegetable, hydrogenated Methyl salicylate Kresoxim-methyl Methyl Methyl acetate vardenafil Tadalafil Hydrocortisone-17-butyrate Sildenafil Danazol Sodium hydride Methylparaben Hydrocortisone Thiophanate-methyl Potassium hydride Bensulfuron methyl