ChemicalBook > Product Catalog >API >Hormones and the Endocrine System >Erectile Dysfunction Treatment >Tadalafil


Cialis is tadalafil, is an orally administrated drug developed by the pharmaceutical company Eli Lily for treatment of male erectile dysfunction disease. It belongs to the second generation of phosphodiesterase type 5 inhibitors. Study has shown that compared with sildenafil, the onset rate of Cialis is very rapid with about 15 ~ 20 min for onset and with long-term effects up to 36h.
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Products Intro:Product Name:Cialis
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Products Intro:CAS:171596-29-5
Purity:99% Package:5g 100g 1kg
Tadalafil Basic information
Indications and uses Clinical Research Side effects Warnings and precautions
Product Name:Tadalafil
Synonyms:TADALAFIL;CIALIS;IC 351;(6r,12ar)-6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-methyl-pyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione;TADALAFIL(CIALIS);Taladafil (cialis);Cialis/taladafil;Cialis(IC351)
Product Categories:Active Pharmaceutical Ingredients;Cnbio;Erectile Dysfunction;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;API's;Steroid and Hormone;Inhibitor;API;Tadalafil;NUCYNTA;Pyridines ,Halogenated Heterocycles
Mol File:171596-29-5.mol
Tadalafil Structure
Tadalafil Chemical Properties
Melting point 298-300°C
storage temp. Hygroscopic, -20?C Freezer, Under Inert Atmosphere
CAS DataBase Reference171596-29-5(CAS DataBase Reference)
Safety Information
Hazard Codes F,Xn
Risk Statements 11-20/21/22-36
Safety Statements 16-36/37
Hazardous Substances Data171596-29-5(Hazardous Substances Data)
MSDS Information
Tadalafil Usage And Synthesis
Indications and usesCialis (or Tadalafil) was developed by American pharmaceutical company Lilly. It is used to treat erectile dysfunction and belongs to a second generation of PDE5 inhibitors. Studies show that Cialis works very quickly, taking effect in around 15-20 minutes, and has a prolonged effect that can last for up to 36 hours. T1/2 is 17.5h.
Clinical ResearchIn a study of 348 cases of mild to severe erectile dysfunction, patients were randomly given 20mg of Cialis or a placebo. Results showed that in comparison to the placebo group, patients who took Cialis experienced improved intercourse success in the 24-36 hours following medication, with many patients achieving successful sexual intercourse twice in 36 hours. Side effect rate and severity were also no different from those of the placebo group. Over 5% of patients in the Cialis group experienced headaches and indigestion.
Side effectsNo severe negative reactions. No perceived facial flushing or sight abnormalities following medication. Rare cases of headache and indigestion.
Warnings and precautionsPatients currently taking nitrates, experiencing angina pectoris, suffering from heart disease, patients who have unregulated hypertension or hypotension, or patients who have had a stroke in the past 6 months should not take Cialis.
Chemical PropertiesWhite to Off-White Cyrstalline Solid
UsesUsed for the treatment of erectile dysfunction. A phosphodiesterase 5 inhibitor
Usesanalgesic, norepinephrine uptake blocker, mu-opiod receptor agonist
DefinitionChEBI: A pyrazinopyridoindole that is 2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione substituted at position 2 by a methyl group and at position 6 by a 1,3-benzodioxol-5-yl group (the 6R,12aR
Tadalafil Preparation Products And Raw materials
Tag:Tadalafil(171596-29-5) Related Product Information
2-Methylpyrazine Sodium hydrosulfide Oils, vegetable, hydrogenated Methyl salicylate Kresoxim-methyl Methyl Methyl acetate vardenafil Tadalafil Hydrocortisone-17-butyrate Sildenafil Danazol Sodium hydride Methylparaben Hydrocortisone Thiophanate-methyl Potassium hydride Bensulfuron methyl