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| | 2-Amino-5-bromo-3-(hydroxymethyl)pyridine Basic information |
| | 2-Amino-5-bromo-3-(hydroxymethyl)pyridine Chemical Properties |
| Melting point | 137-140°C | | Boiling point | 343.5±37.0 °C(Predicted) | | density | 1.766±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | solubility | Acetone, Ethyl Acetate, Methanol | | pka | 13.16±0.10(Predicted) | | form | Solid | | color | Off-white to yellow | | CAS DataBase Reference | 335031-01-1(CAS DataBase Reference) |
| Hazard Codes | Xi | | HazardClass | IRRITANT | | HS Code | 2933399990 |
| | 2-Amino-5-bromo-3-(hydroxymethyl)pyridine Usage And Synthesis |
| Uses | 2-Amino-5-bromo-3-(hydroxymethyl)pyridine can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process. | | Synthesis | 2-Amino-5-bromo-3-(hydroxymethyl)pyridineBromine (8.4 mL, 189.4 mmol) was added dropwise over 1 hour to a solution of 2- amino-3-(hydroxymethyl)pyridine (19.6 g, 157.8 mmol) in acetic acid (350 mL) at room temperature. The reaction mixture was then stirred overnight. After concentration to dryness, the residue was partitioned between a saturated solution of potassium carbonate (300 mL) and ethyl acetate (200 ml_). The aqueous layer was separated and extracted with ethyl acetate (2 x 200 ml_). The combined organic phases were washed with a saturated solution of sodium chloride (200 ml_), dried over sodium sulfate, filtered and concentrated to dryness. After trituration of the residue in pentane, the title product was obtained as a yellow solid (27.0 g, 84%). |
| | 2-Amino-5-bromo-3-(hydroxymethyl)pyridine Preparation Products And Raw materials |
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