| Company Name: |
Syntechem Co.,Ltd
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| Tel: |
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| Email: |
info@syntechem.com |
| Products Intro: |
Product Name:(Z)-2-aMino-N,3-dihydroxypropaniMidic acid
CAS:55779-32-3
Purity:97% Package:1g;5g;25g;100g;250g;1kg;5kg;10kg;25kg Remarks:we offer low price custom synthesis and contract manufacturing
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| Company Name: |
Guangzhou Isun Pharmaceutical Co., Ltd
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020-39119399 18927568969 |
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isunpharm@qq.com |
| Products Intro: |
Product Name:DL-Serine hydroxaMate seryl-tRNA synthetase inhibitor
CAS:55779-32-3
Purity:>=98.0% Package:25Mg; 1g; 100g; 500g
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| Company Name: |
Sigma-Aldrich
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021-61415566 800-8193336 |
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orderCN@merckgroup.com |
| Products Intro: |
Product Name:DL-Serine hydroxamate
CAS:55779-32-3
Purity:seryl-tRNA synthetase inhibitor Package:1G Remarks:S4503-1G
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| | AMINO ACID HYDROXAMATES DL-SERINE HYDROXAMATE Basic information |
| | AMINO ACID HYDROXAMATES DL-SERINE HYDROXAMATE Chemical Properties |
| | AMINO ACID HYDROXAMATES DL-SERINE HYDROXAMATE Usage And Synthesis |
| Uses | Serine has been used as an inhibitor of seryl-tRNA synthetase. DL-Serine hydroxamate is used to induce metabolic synthesis of guanosine 3′-diphosphate 5′-diphosphate (ppGpp) in E. coli by amino acid starvation. It is also used to synchronize cell cycle in E. coli cultures by inhibition of tRNA charging. | | Definition | ChEBI: Serine hydroxamate is a hydroxamic acid obtained by formal condensation of the carboxy group of serine with the amino group of hydroxylamine. It has a role as an EC 6.1.1.11 (serine--tRNA ligase) inhibitor. It is a hydroxamic acid and a serine derivative. | | Biochem/physiol Actions | Serine is involved in the one-carbon unit metabolism. It is associated with the biosynthesis of cysteine, ceramide, phosphatidylserine, purine and pyrimidine. In bacteria, it participates in tryptophan synthesis. Gluconeogenesis, one of the important biochemical processes, involves serine, particularly in ruminants. Protein phosphorylation is one such event that utilizes serine. Glycine, a metabolic product of serine, serves as an antioxidant and a neurotransmitter. D-serine is known to activate the N-methyl-D-aspartate (NMDA) receptors of the brain. Serine hydroxamate, a structural analogue of serine prevents seryl-tRNA (transfer ribonucleic acid) charging and thereby decreases phospholipid and nucleic acid synthesis in Escherichia coli. |
| | AMINO ACID HYDROXAMATES DL-SERINE HYDROXAMATE Preparation Products And Raw materials |
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