- shikimic acid
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- $160.00 / 1KG
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2024-04-26
- CAS:138-59-0
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 1000kg
- shikimic acid
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- $0.00 / 1kg
-
2024-04-23
- CAS:138-59-0
- Min. Order: 1kg
- Purity: 98%
- Supply Ability: 1000kg
- Puer Natural Shikimic Acid
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- $10.00 / 1kg
-
2024-04-23
- CAS:138-59-0
- Min. Order: 1kg
- Purity: 98.0% Shikimic Acid Test by HPLC
- Supply Ability: 10000
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| | Shikimic acid Basic information |
| | Shikimic acid Chemical Properties |
| Melting point | 185-187 °C (lit.) | | Boiling point | 225.11°C (rough estimate) | | alpha | -180 º (c=4, H2O 25 ºC) | | density | 1.52 g/cm3 (27.2℃) | | vapor pressure | 0Pa at 25℃ | | refractive index | -180 ° (C=1, H2O) | | storage temp. | 2-8°C | | solubility | 180g/l | | form | Powder | | pka | pK (14.1°) 5.19 | | color | White to light beige or light gray | | optical activity | [α]/D -180.0±5.0°, c = 4 in H2O | | Water Solubility | 18 g/100 mL (20 ºC) | | Sensitive | Hygroscopic | | Merck | 14,8480 | | BRN | 4782717 | | InChIKey | JXOHGGNKMLTUBP-HSUXUTPPSA-N | | LogP | -1.5 at 21℃ and pH1 | | Surface tension | 49.86mN/m at 1g/L and 20℃ | | CAS DataBase Reference | 138-59-0(CAS DataBase Reference) | | NIST Chemistry Reference | Shikimic acid(138-59-0) | | IARC | 3 (Vol. 40, Sup 7) 1987 |
| | Shikimic acid Usage And Synthesis |
| Description | Shikimic acid (3,4,5-trihydroxy-1-cyclohexene-1-carboxylic acid) is a natural organic compound. Plant and microbial sources are the only sources of this compound. The isolation of shikimic acid from the fruit of Illicium religiosum was primarily reported by Ekmann in 1885. The name shikimic acid was derived from the oriental plant shikimi-no-ki in Japanese. It is now available in more quantities through the extraction from the fruit Illicium verum (Chinese star anise). This compound is generally utilized as a starting material for the industrial synthesis of the antiviral oseltamivir, a drug against the H1N1 influenza virus. It is also an essential intermediate in the biosynthesis of lignin, aromatic amino acids (phenylalanine, tyrosine, and tryptophan), and most alkaloids of plants and microorganisms[1]. The neuraminidase inhibitors oseltamivir or Tamiflu derived from the shikimic acid pathway are potent influenza viral neuraminidase inhibitors against most influenza strains ( influenza A and B infections). The mode of application is by mouth, either in the form of a pill or liquid. | | Chemical Properties | White Solid | | Uses | Shikimic acid has been used as a standard for the quantification of shikimate in apical parts of roots. It has also been used as a substrate in shikimate kinase assay. | | Uses | Naturally occurring (-)-form is a major biosynthetic precursor of phenylalanine, tyrosine, and tryptophan and hence of the majority of plant alkaloids. It is also involved in the biosynthesis of lignin, flavonpids and other important aromatic compounds. | | Definition | ChEBI: A cyclohexenecarboxylic acid that is cyclohex-1-ene-1-carboxylic acid substituted by hydroxy groups at positions 3, 4 and 5 (the 3R,4S,5R stereoisomer). It is an intermediate metabolite in plants and micro
rganisms. | | Biochem/physiol Actions | Shikimic acid is observed to be carcinogenic in rat models, when administered. It serves as a precursor for the biosynthesis of aromatic amino acids, alkaloids and other aromatic metabolites in microorganisms. Shikimic acid is known to inhibit adenosine diphosphate (ADP) induced platelet aggregation and blood coagulation in rabbits. | | References | [1] Priyanka Singh. “Shikimic acid as intermediary model for the production of drugs effective against influenza virus.” Phytochemicals as Lead Compounds for New Drug Discovery 14 1 (2020): 245–256. |
| | Shikimic acid Preparation Products And Raw materials |
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