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主な危険性 | Xi,F | Rフレーズ | 36/37/38-10 | Sフレーズ | 26-36-36/37/39-16 | RIDADR | UN 1989 | WGK Germany | 1 | RTECS 番号 | NR9400000 | F | 8-10-23 | Hazard Note | Irritant/Keep Cold/Air Sensitive | TSCA | Yes | 国連危険物分類 | 3.2 | 容器等級 | III | HSコード | 29333999 | 毒性 | LD50 orally in Rabbit: 2355 mg/kg LD50 dermal Rat > 2000 mg/kg |
| 4-ピリジンカルボキシアルデヒド Usage And Synthesis |
化学的特性 | clear yellow-brown liquid. soluble in water and ether. | 使用 | 4-Pyridinecarboxaldehyde can be used for the synthesis of:
- ?,β-Unsaturated amides by coupling with N,N-disubstituted formamides.
- meso-Substituted A3-corroles.
- N-(4-pyridylmethyl)-L-valine as a ligand to construct zinc metal–organic frameworks (Zn-MOFs).
- 4′-Pyridyl terpyridines, with potential application as anticancer and antimicrobial agents.
- 4-pyridinecarboxaldehyde thiosemicarbazone, as a corrosion inhibitor for mild steel.
| 使用 | 4-Pyridinecarboxaldehyde, is an heterocyclic building block used for the synthesis of various pharmaceutical compounds, such as new 1,4-dihydropyridin-4-yl-phenoxyacetohydrazones, having anticonvulsant and anti-inflammatory properties. | 製造方法 | 4-Pyridinecarbaldehyde is synthesized by oxidation of 4-picoline. The mixed gas of 4-picoline and air is passed through the vanadium-molybdenum catalyst layer heated to 400°C, and oxidized to generate 4-pyridinecarbaldehyde. | Synthesis Reference(s) | Synthetic Communications, 20, p. 3385, 1990 DOI: 10.1080/00397919008051576 | 純化方法 | Purified as for pyridine-2-aldehyde. [Beilstein 21 III/IV 2529, 21/7 V 351.] |
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