ChemicalBook > Product Catalog >API >Hormones and the Endocrine System >Sex Hormone Drugs >Triptorelin

Triptorelin

Triptorelin Suppliers list
Company Name: Shenzhen Sendi Biotechnology Co.Ltd.
Tel: 0755-23311925 18102838259
Email: Abel@chembj.com
Products Intro: Product Name:Triptorelin
CAS:57773-63-4
Purity:99% Package:2250/G
Company Name: Hangzhou Peptide Biochem Co.,Ltd  Gold
Tel:86-0571-89197072,18668118770
Email:linda@peptide-manufacturer.com
Products Intro:Product Name:Triptorelin Acetate
CAS:57773-63-4
Purity:98.5% Package:1g,10g,25g,100g Remarks:USP,EP
Company Name: Cellmano Biotech Limited  Gold
Tel:+86-551-65326643
Email:info@cellmano.com
Products Intro:Product Name:Triptorelin Acetate
CAS:57773-63-4
Purity:98% HPLC Package:5Mg;10Mg;1g
Company Name: Arden pharmaceutical &chemical Co., Ltd  
Tel:+86-(0)533-3595900 13793319233
Email:info@chems.com.cn
Products Intro:Product Name:Triptorelin Acetate
CAS:57773-63-4
Purity:>=98% Package:as your request
Company Name: Chembest Research Laboratories Limited  
Tel:+86(0)21-20908456
Email:sales@biochembest.com; market@biochembest.com
Products Intro:Product Name:Triptorelin Acetate
CAS:57773-63-4
Remarks:C14297
Triptorelin Basic information
Antineoplastic drug
Product Name:Triptorelin
Synonyms:PGLU-HIS-TRP-SER-TYR-D-TRP-LEU-ARG-PRO-GLY-NH2;PYROGLU-HIS-TRP-SER-TYR-D-TRP-LEU-ARG-PRO-GLY NH2;PYR-HIS-TRP-SER-TYR-D-TRP-LEU-ARG-PRO-GLY-NH2;PYR-HIS-TRP-SER-TYR-D-TRP-LEU-ARG-PRO-GLY-NH2 PAMOATE SALT;TRIPTORELIN PAMOATE;TRIPTORELIN ACETATE;TRIPTORELIN AMIDE;TRIPTORELIN, [DTRP6]-LH-RH, AMIDE
CAS:57773-63-4
MF:C64H82N18O13
MW:1311.45
EINECS:
Product Categories:Amino Acid Derivatives;Peptide
Mol File:57773-63-4.mol
Triptorelin Structure
Triptorelin Chemical Properties
storage temp. −20°C
form powder
CAS DataBase Reference57773-63-4(CAS DataBase Reference)
Safety Information
Hazard Codes T
Risk Statements 60
Safety Statements 53-22-36/37/39-45
WGK Germany 3
MSDS Information
ProviderLanguage
SigmaAldrich English
Triptorelin Usage And Synthesis
Antineoplastic drugThe active ingredient of triptorelin is a synthetic gonadotropin-releasing hormone (GnRH) analogue, which is also known as decapeptyl, diphereline, triptorelin acetate, gonadorelin. It is an antineoplastic drug, whose pharmacological effects are same with goserelin, buserelin, and its structure is modified by natural molecular structure of the sixth L-glycine that is replaced by D-tryptophan to promote efficiency and prolong the plasmic half-life time, as well as enhance drug efficacy. After intramuscular injection, it initially stimulates the pituitary gland to release luteinizing growth hormone (LH) and follicle-stimulating hormone (FSH). When the pituitary over a long period of stimulation will be into the refractory period, that reduced the release of gonadotropin, leading to sex hormones reduction to castrate levels. These effects are reversible. Subcutaneous administration is rapidly absorbed, and Tmax is 15min, and the effect is maximum at 1h. The intramuscular injection of sustained release formulations can maintain the efficacy reaching 28d or more. It Clinically uses for the treatment of endometriosis, hormone-dependent prostate cancer, breast cancer, precocious puberty, as well as it may also be used as assisted reproductive technology. The main side effects of triptorelin are as follows: In the early stage of treatment of male, it can cause urinary disorders, breast swelling and pain, bone pain, and it may also cause hot flashes, loss of libido and impotence. It rarely cause gynecomastia, testicular atrophy, and sleep disorders. In the first week of treatment for children, girls will occur small amount of vaginal bleeding, which can be corrected by short-term additional therapy. During the treatment of women, hot flashes, bleeding or bleeding spots, vaginal dryness, headaches and weakness can occur. It can cause abdominal and (or) pelvic pain when it uses combination with gonadotropin. Since the concentration of estrogen reduces to the level of post-menopause, it can cause slight loss of trabecular bone matrix. Generally, after cessation of treatment six to nine months the adverse reations can return to normal. There may be irreversible amenorrhea after treatment in patients with endometriosis.
The above information is edited by the chemicalbook of Kui Ming.
Usespromoting ovulation
DefinitionChEBI: An oligopeptide comprising pyroglutamyl, histidyl, tryptophyl, seryl, tyrosyl, D-tryptophyl, leucyl, arginyl, prolyl and glycinamide residues joined in sequence. It is an agonist analogue of gonadotropin-releasing hormone.
Triptorelin Preparation Products And Raw materials
Tag:Triptorelin(57773-63-4) Related Product Information
Leuprorelin (D-LEU7)-TRIPTORELIN (TRP6)-TRIPTORELIN (D-TYR5)-TRIPTORELIN [D-TRP6]-LH-RH-LEU-ARG-PRO-GLY-NH2 TRIPTORELIN-LEU-ARG-PRO-GLY AMIDE,(D-SER4)-TRIPTORELIN (DES-PYR1)-TRIPTORELIN [D-TRP6]-LHRH FRAGMENT, 1-6 TRIPTORELIN 1-6 AMIDE,TRIPTORELIN (1-6) AMIDE TRIPTERYGLLHYPOGLAUCIDRIEDPOWDER FORMYL-TRIPTORELIN (2-10) (D-HIS2)-TRIPTORELIN TRIPTORELIN (FREE ACID) TRIPTORELIN-LEU-ARG-PRO-GLY AMIDE GLP-HIS-TRP-SER-TYR-DTRP-LEU-ARG-PRO-GLY-NHET Triptorelin