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| | CIS-3-AMINOCYCLOBUTANECARBOXYLIC ACID Basic information |
| Product Name: | CIS-3-AMINOCYCLOBUTANECARBOXYLIC ACID | | Synonyms: | CIS-3-AMINOCYCLOBUTANECARBOXYLIC ACID;3-aminocyclobutane-1-carboxylic acid;cis-3-Amino-cyclobutaneca...;rel-(1R,3R)-3-aMinocyclobutane-1-carboxylic acid;cis-3-aminocyclobutane-1-carboxylic acid;Cyclobutanecarboxylic acid, 3-amino-, cis- | | CAS: | 74316-27-1 | | MF: | C5H9NO2 | | MW: | 115.13 | | EINECS: | | | Product Categories: | | | Mol File: | 74316-27-1.mol |  |
| | CIS-3-AMINOCYCLOBUTANECARBOXYLIC ACID Chemical Properties |
| Melting point | >250 °C (decomp) | | Boiling point | 251.0±33.0 °C(Predicted) | | density | 1.267±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | pka | 3.67±0.20(Predicted) |
| Hazard Codes | Xi | | Hazard Note | Irritant | | HS Code | 2916399090 |
| | CIS-3-AMINOCYCLOBUTANECARBOXYLIC ACID Usage And Synthesis |
| Uses | CIS-3-AMINOCYCLOBUTANECARBOXYLIC ACID can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process. | | Synthesis | 
Azide 10a (0.30 g, 1.9 mmol) was dissolved in methanol (5 mL); then 6N HCl (2 mL) and 10% palladium on charcoal were added to the solution. The resulting mixture was stirred under 1 bar of hydrogen for 3 h, then the catalyst was filtered off, and the solvent was removed under reduced pressure. The residue was dissolvedin 6N HCl (5 mL) and refluxed upon stirring for 1 h, then evaporated in vacuum. The residue was purified by ion-exchange chromatography (Amberlite? IR-120(plus) ion-exchange resin, 3.5% aqueous ammonia as an eluent). cis-3-aminocyclobutanecarboxylic acid 1a as white powder, yield 0.16 g, 1.4 mmol, 71%. |
| | CIS-3-AMINOCYCLOBUTANECARBOXYLIC ACID Preparation Products And Raw materials |
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