肉豆蔻油酸
| 中文名称 | 肉豆蔻油酸 |
|---|---|
| 中文同义词 | (Z)-9-十四烯酸;肉豆蔻油酸;顺9-肉豆蔻烯酸;十四碳烯酸(顺-9);顺-9-十四碳烯酸/肉豆蔻油酸;肉豆蔻脑酸;9-十四烯酸;十四碳烯酸(顺-9)(C14:1) |
| 英文名称 | MYRISTOLEIC ACID |
| 英文同义词 | DELTA 9 CIS TETRADECENOIC ACID;C14:1 (CIS-9) ACID;(Z)-tetradec-9-enoic acid;MYRISTOLEIC ACID 99%;9-Tetradecenoic acid, (9Z)-;(9Z)-9-Tetradecenoic acid;Myristolenic acid;9-cis-Tetradecenoic acid |
| CAS号 | 544-64-9 |
| 分子式 | C14H26O2 |
| 分子量 | 226.35 |
| EINECS号 | 208-876-8 |
| 相关类别 | 脂肪酸;中间体 |
| Mol文件 | 544-64-9.mol |
| 结构式 |  |
肉豆蔻油酸 性质
| 熔点 | −4.5-−4 °C(lit.) |
|---|---|
| 沸点 | 144 °C0.6 mm Hg(lit.) |
| 密度 | 0.9 g/mL at 25 °C(lit.) |
| 折射率 | n |
| 闪点 | 62 °C |
| 储存条件 | -20°C |
| 溶解度 | 苯（微量）、氯仿（微量）、甲醇（微量） |
| 形态 | 液体 |
| 酸度系数(pKa) | 4.78±0.10(Predicted) |
| 颜色 | 无色 |
| LogP | 5.383 (est) |
| EPA化学物质信息 | 9-Tetradecenoic acid, (9Z)- (544-64-9) |
Myristoleic acid 是 Serenoa repens 提取物中的一种细胞毒性成分，可诱导人前列腺细胞的凋亡和坏死。
Myristoleic acid induces both apoptosis (100 μg/mL, 89.5%) and necrosis (100 μg/mL, 81.8%) in LNCaP cells.
Myristoleic acid inhibited RANKL-induced osteoclast formation in vitro, especially, at later stages of differentiation.
Cell Proliferation Assay
| Cell Line: | Human prostatic carcinoma LNCaP cells. |
| Concentration: | 0, 50, 100, 150, 200, 250 μg/mL. |
| Incubation Time: | 24 h. |
| Result: | When LNCaP cells were treated with 130 μg/mL extract or 100 μg/mL myristoleic acid for 24 hr, the proportion of apoptotic cells was 16.5 and 8.8%, and that of necrotic one was 46.8 and 81.8%, respectively. |
Myristoleic acid (2 mg/kg, IP every 24 h for 4 days) prevents RANKL-induced bone loss and osteoclast formation in mice.
| Animal Model: |
C57BL/6 mice at 5 weeks.
|
| Dosage: | 0.2, 2 mg/kg |
| Administration: | IP every 24 h for 4 days. |
| Result: | Co-administration of myristoleic acid suppressed generation of TRAP-positive osteoclasts induced by sRANKL and attenuated the increases in osteoclastic indices of Oc.S/BS, N.Oc/B. Pm and ES/BS in a dose-dependent manner. |
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英文
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