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1-NAPHTHOHYDROXAMIC ACID

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1-NAPHTHOHYDROXAMIC ACID Suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:1-Naphthohydroxamic acid
CAS:6953-61-3
Purity:98.00% Package:1 mL * 10mM (in DMSO)；10 mg；100 mg；200 mg；5 mg；50 mg；500 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Career Henan Chemica Co
Tel: +86-0371-86658258 15093356674;
Email: laboratory@coreychem.com
Products Intro: Product Name:1-NAPHTHOHYDROXAMIC ACID
CAS:6953-61-3
Purity:99% Package:1KG;9.20USD
Company Name: Dayang Chem (Hangzhou) Co.,Ltd.
Tel: 571-88938639 +8617705817739
Email: info@dycnchem.com
Products Intro: Product Name:1-Naphthohydroxamic Acid
CAS:6953-61-3
Purity:0.95&0.99 Package:0.1KG;1KG;1000KG Remarks:Top Quality
Company Name: Hangzhou MolCore BioPharmatech Co.,Ltd.
Tel: +86-057181025280; +8617767106207
Email: sales@molcore.com
Products Intro: Product Name:1-Naphthohydroxamic acid
CAS:6953-61-3
Purity:NLT 98% Remarks:MC567687
Company Name: GIHI CHEMICALS CO.,LIMITED
Tel: +8618058761490
Email: info@gihichemicals.com
Products Intro: Product Name:1-Naphthohydroxamic Acid
CAS:6953-61-3
Purity:99 Package:5KG;1KG,25kg
1-NAPHTHOHYDROXAMIC ACID Basic information
Product Name:1-NAPHTHOHYDROXAMIC ACID
Synonyms:Naphthalene-1-carbohydroximic acid;N-Hydroxy-1-naphthalenecarboxamide;a-Naphthohydroxamic acid;NSC 57457;HDAC Inhibitor XIX, Compound 2;N-HYDROXYNAPHTHALENE-1-CARBOXAMIDE;alpha-naphthohydroxamicacid;n-hydroxy-1-naphthalenecarboxamid
CAS:6953-61-3
MF:C11H9NO2
MW:187.19
EINECS:
Product Categories:Hydroxylamines;Hydroxylamines (N-Substituted)
Mol File:6953-61-3.mol
1-NAPHTHOHYDROXAMIC ACID Structure
1-NAPHTHOHYDROXAMIC ACID Chemical Properties
Melting point 176-178 °C
density 1.291±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: ≥5mg/mL
form White solid
pka8.91±0.30(Predicted)
color white to tan
Safety Information
Risk Statements 52
WGK Germany 3
RTECS QJ1894500
HS Code 2928009090
MSDS Information
1-NAPHTHOHYDROXAMIC ACID Usage And Synthesis
Uses1-Naphthohydroxamic Acid is a potent HDAC inhibitor with efficacy against HDAC8, HDAC1 and HDAC6.
Biochem/physiol Actions1-Naphthohydroxamic Acid is a cell-permeable, potent, and selective histone deacetylase 8 (HDAC8) inhibitor. 1-Naphthohydroxamic acid selectively inhibits HDAC8 (IC50 = 14 μM) over class I HDAC1 and class II HDAC6 (IC50 >100 μM). Treatment of cells with 1-Naphthohydroxamic acid does not increase neither global histone H4 nor tubulin acetylation . Also in contrast to the pan-HDAC inhibitors the compound is not reducing total intracellular HDAC activity.
1-NAPHTHOHYDROXAMIC ACID Preparation Products And Raw materials
Tag:1-NAPHTHOHYDROXAMIC ACID(6953-61-3) Related Product Information
Pyrazine 2-Naphthohydroxamic acid, O-acetate ester Naftalofos N-HYDROXYNAPHTHALIMIDE SODIUM SALT N-Hydroxy-1,8-naphthalimide Naphthaloximidodiethyl thiophosphate N-Hydroxynaphthalimide triflate 1-NAPHTHOHYDROXAMIC ACID