Tioxolone manufacturers
- Tioxolone
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- $1.00 / 1IU
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2019-12-29
- CAS:4991-65-5
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 100kg
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| | Tioxolone Basic information |
| Product Name: | Tioxolone | | Synonyms: | thioxolon;Thiphen;tioxolon;6-HYDROXY-1,3-BENZOXANTHIOL-2-ONE;6-HYDROXY-1,3-BENZOXATHIOL-2-ONE, 98+%;6-Hydroxy-2-oxo-1,3-benzoxathiole;6-Hydroxy-2-oxobenzoxathiole;Acnosan | | CAS: | 4991-65-5 | | MF: | C7H4O3S | | MW: | 168.17 | | EINECS: | 225-653-0 | | Product Categories: | Heterocyclic Compounds;STEPIN | | Mol File: | 4991-65-5.mol |  |
| | Tioxolone Chemical Properties |
| Melting point | 158-160 °C(lit.) | | Boiling point | 267.1°C (rough estimate) | | density | 1.4844 (rough estimate) | | refractive index | 1.5151 (estimate) | | storage temp. | Inert atmosphere,Room Temperature | | solubility | 95% ethanol: soluble50mg/mL, clear to very slightly hazy, colorless to yellow | | form | A solid | | pka | 8.14±0.20(Predicted) | | Merck | 9456 | | LogP | 1.770 (est) | | CAS DataBase Reference | 4991-65-5(CAS DataBase Reference) | | NIST Chemistry Reference | Tioxolone(4991-65-5) |
| Hazard Codes | Xn,Xi | | Risk Statements | 22-36/37/38 | | Safety Statements | 26 | | WGK Germany | 3 | | RTECS | DM2953750 | | HS Code | 2934999090 |
| | Tioxolone Usage And Synthesis |
| Chemical Properties | light yellow to beige powder | | Originator | Acnosan,Unia | | Uses | 6-Hydroxy-1,3-benzoxathiol-2-one was used in the synthesis of heterocycle-phosphor esters having potential antimicrobial activity. | | Uses | antiseborrhoic | | Definition | ChEBI: A 1,3-benzoxathiole having a hydroxy substituent at the 6-position. | | Manufacturing Process | 40 g potassium thiocyanate in 50 ml of water are added, while stirring at
room temperature, to a solution of 11 g of resorcinol and 50 g of crystallized
copper sulfate in 250 ml of water. The black cupric thiocyanate formed
becomes colorless after a short time, which indicates that the introduction of
thiocyanogen is terminated. The cuprous thiocyanate is removed by filtering
with suction and then washed with water; the filtrate is mixed with 50 ml of a
2 N sodium carbonate solution, whereby the imino-thiocarbonate of resorcinol
separates in the form of a colorless crystalline body. The yield amounts to 16
g. The new compound which melts at 149°C dissolves very easily in many
organic solvents and in mineral acids.
A 10% solution of the imino-thiocarbonate of resorcinol in 10% hydrochloric
acid is heated for 15 min on the steam bath. The 6-hydroxy-1,3-benzoxathiol-
2-one (thiocarbonate free from) nitrogen separates, on cooling, in the form of
fine crystals melting at 158°C. | | Therapeutic Function | Antiseborreic, Antifungal, Keratolytic | | General Description | Antimicrobial and cytostatic properties of 6-hydroxy-1,3-benzoxathiol-2-one has been investigated. Supramolecular structure of 6-hydroxy-1,3-benzoxathiol-2-one has been studied. |
| | Tioxolone Preparation Products And Raw materials |
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