哌罗匹隆
| 中文名称 | 哌罗匹隆 |
|---|---|
| 中文同义词 | (3AS,7AR)-2-[4-[4-(1,2-苯并噻唑-3-基)哌嗪-1-基]丁基]-3A,4,5,6,7,7A-六氢异吲哚-1,3-二酮;哌罗匹隆杂质;哌罗匹隆;哌罗匹隆相关杂质 |
| 英文名称 | PEROSPIRONE |
| 英文同义词 | PEROSPIRONE;PEROSPIRONE HCL;1H-Isoindole-1,3(2H)-dione, 2-[4-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]butyl]hexahydro-, (3aR,7aS)-rel- (9CI);1H-Isoindole-1,3(2H)-dione, 2-[4-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]butyl]hexahydro-, cis-;cis-N-[4-[4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl]butyl]-1,2-cyclohexanedicarboximide;Perospirine;(1R,2S)-N-[4-[4-(1,2-Benzisothiazole-3-yl)-1-piperazinyl]butyl]cyclohexane-1,2-dicarbimide;(3aα,7aα)-2-[4-[4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl]butyl]hexahydro-1H-isoindole-1,3(2H)-dione |
| CAS号 | 150915-41-6 |
| 分子式 | C23H30N4O2S |
| 分子量 | 426.57 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 150915-41-6.mol |
| 结构式 |  |
哌罗匹隆 性质
| 储存条件 | Store at -20°C |
|---|---|
| 溶解度 | 溶于二甲基亚砜 |
| 形态 | 固体 |
| 颜色 | 白色至类白色 |
|
5-HT 2A Receptor 0.6 nM (Ki) |
Dopamine D 2 1.4 nM (Ki) |
5-HT 1A Receptor 2.9 nM (Ki) |
5-HT 1 Receptor 18 nM (Ki) |
Dopamine D 1 41 nM (Ki) |
Perospirone (SM-9018 free base) possesses moderate affinities for α 1 , 5-HT 1 , and D 1 receptors (K i =17, 18 and 41 nM, respectively) .
Perospirone (SM-9018 free base; 1.0-10.0 mg/kg/day; orally; for 14 consecutive days) significantly attenuates PCP-induced cognitive deficits in mice in a dose-dependent manner.
| Animal Model: | Male ICR mice (6 weeks old) weighing 25-30 g |
| Dosage: | 1.0, 3.0 or 10.0 mg/kg |
| Administration: | Orally; daily; for 14 consecutive days |
| Result: | Significantly attenuated PCP-induced cognitive deficits in mice in a dose-dependent manner. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-B0731A | 哌罗匹隆 Perospirone | 150915-41-6 | 10mg | 1200元 |
| 2024/04/30 | HY-B0731A | 哌罗匹隆 Perospirone | 150915-41-6 | 50mg | 4200元 |