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Product Name:4,4-Dimethyl-3,5,8-trioxabic-yclo[5,1,0]Octane
CAS:57280-22-5
Purity:98%(Min,HPLC) Package:100g;1kg;5kg,10kg,25kg,50kg
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| | 4,4-Dimethyl-3,5,8-trioxabic-yclo[5,1,0]Octane Basic information |
| Product Name: | 4,4-Dimethyl-3,5,8-trioxabic-yclo[5,1,0]Octane | | Synonyms: | 4,4-Dimethyl-3,5,8-trioxabic-yclo[5,1,0]Octane;3,5,8-Trioxabicyclo[5.1.0]octane, 4,4-diMethyl-;4,4-diMethyl-3,5,8-trioxabicyclo[5.1.0]octane(EP2);4,4-Dimethyl-3,5,8-trioxabic-yclo[5.1.0]octane(DTC-octane);Gadobutrol Impurity 49;4 4-DIMETHYL-3 5 8-TRIOXABICYCLO (5.1.0)OCTANE TOBO;0]Octane;4-Dimethyl-3 | | CAS: | 57280-22-5 | | MF: | C7H12O3 | | MW: | 144.17 | | EINECS: | 421-750-9 | | Product Categories: | 57280-22-5 | | Mol File: | 57280-22-5.mol | ![4,4-Dimethyl-3,5,8-trioxabic-yclo[5,1,0]Octane Structure](CAS/GIF/57280-22-5.gif) |
| | 4,4-Dimethyl-3,5,8-trioxabic-yclo[5,1,0]Octane Chemical Properties |
| Boiling point | 179℃ | | density | 1.071 | | refractive index | 1.4560 to 1.4600 | | Fp | 56℃ | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | form | clear liquid | | color | Colorless to Light yellow to Light orange |
| | 4,4-Dimethyl-3,5,8-trioxabic-yclo[5,1,0]Octane Usage And Synthesis |
| Chemical Properties | Clear colorless to yellow liquid | | Uses | 4,4-Dimethyl-3,5,8-trioxabicyclo[5.1.0]octane is used in the CO2-mediated formation of chiral carbamates from meso-epoxides via polycarbonate intermediates and amine nucleophiles, which opens up a wide a wide range of CO2-based carbamate scaffolds with excellent yields and 99% enantiomeric excess. | | Application | 4, 4-dimethyl-3,5, 8-trioxane [5,1,0] octane is a key intermediate in the preparation of gadobinol. As a meso epoxide, it could be used to obtain optically pure ABT derivatives through Ti(IV)/BINOL catalyzed asymmetric aminolysis[1]. | | References | [1] Bao H, et al. Insight into the Mechanism of the Asymmetric Ring-Opening Aminolysis of 4,4-Dimethyl-3,5,8-trioxabicyclo[5.1.0]octane Catalyzed by Titanium/BINOLate/Water System: Evidence for the Ti(BINOLate)2-Bearing Active Catalyst Entities and the Role of Water. Journal of the American Chemical Society, 2008; 130: 10116–10127.
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| | 4,4-Dimethyl-3,5,8-trioxabic-yclo[5,1,0]Octane Preparation Products And Raw materials |
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