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| | SKL 2001 Basic information |
| Product Name: | SKL 2001 | | Synonyms: | SKL 2001;N-(3-(1H-imidazol-1-yl)propyl)-5-(furan-2-yl)isoxazole-3-carboxamide;CS-2771;SKL2001;SKL-2001;SKL 2001;SKL-2001;SKL 2001;5-(furan-2-yl)-N-[3-(1H-imidazol-1-yl)propyl]-1,2-oxazole-3-carboxamide;2001;SKL2001 free base | | CAS: | 909089-13-0 | | MF: | C14H14N4O3 | | MW: | 286.29 | | EINECS: | | | Product Categories: | | | Mol File: | 909089-13-0.mol |  |
| | SKL 2001 Chemical Properties |
| Boiling point | 595.7±50.0 °C(Predicted) | | density | 1.37±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 25 mg/ml; DMSO: 25 mg/ml; Ethanol: 25 mg/ml; Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml | | form | A crystalline solid | | pka | 13.36±0.46(Predicted) |
| | SKL 2001 Usage And Synthesis |
| Description | SKL2001 is an activator of Wnt/β-catenin signaling. It increases β-catenin responsive transcription in a cell-based reporter assay in a concentration-dependent manner, increases β-catenin protein levels in HEK293 cells when used at concentrations of 10 and 30 μM, and disrupts the interaction between Axin and β-catenin. SKL2001 increases alkaline phosphatase (ALP) activity and mineralization in multipotent mesenchymal ST2 cells in a concentration-dependent manner, indicating increased osteoblastogenesis. SKL2001 (40 μM) reduces HCT116 and HT-29 spheroid growth and inhibits proliferation of HCT116 and HT-29 cells. It induces cell cycle arrest at the G0/G1 phase and increases E-cadherin and β-catenin protein levels in HCT116 cells when used at a concentration of 40 μM. |
| | SKL 2001 Preparation Products And Raw materials |
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