Related articles - What is 2,2,6,6-Tetramethylpiperidine?
- 2,2,6,6-Tetramethylpiperidine, abbreviated TMP, HTMP, or TMPH, is an organic compound of the amine class. In appearance, it is....
- Aug 25，2021
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| | 2,2,6,6-Tetramethylpiperidine Basic information |
| Product Name: | 2,2,6,6-Tetramethylpiperidine | | Synonyms: | 2,2,6,6-TETRAMETHYLPIPERIDINE;2,2,6,6-tetramethyl-piperidin;Norpempidine;2,2,6,6-Tetramethylpiperidine (HTMP);2,2,6,6-Tetramethylpiperidine, 98+%;2,2,6,6-TETRAMETHYLPIPERIDINE, 99+%;2,2,6,6-Tetramethylpiperidien;Piperidine, 2,2,6,6-tetramethyl- | | CAS: | 768-66-1 | | MF: | C9H19N | | MW: | 141.25 | | EINECS: | 212-199-3 | | Product Categories: | Fine Chemical;Industrial/Fine Chemicals;Piperidines, Piperidones, Piperazines;Piperidine;API intermediates;Organic BasesBuilding Blocks;Chemical Synthesis;Heterocyclic Building Blocks;Piperidines;Synthetic Reagents;768-66-1 | | Mol File: | 768-66-1.mol |  |
| | 2,2,6,6-Tetramethylpiperidine Chemical Properties |
| Hazard Codes | Xn,F,C | | Risk Statements | 10-22-36/37/38 | | Safety Statements | 26-37/39-16 | | RIDADR | UN 1992 3/PG 3 | | WGK Germany | 2 | | RTECS | TN4220000 | | Autoignition Temperature | 290 °C | | TSCA | Yes | | HazardClass | 3 | | PackingGroup | III | | HS Code | 29333999 | | Toxicity | LD50 orally in Rabbit: 500 mg/kg |
| | 2,2,6,6-Tetramethylpiperidine Usage And Synthesis |
| Chemical Properties | clear colorless to light yellow-green liquid | | Uses | 2,2,6,6-Tetramethylpiperidine is a hindered base used to prepare metallo-amide bases and selective generation of silylketene acetals. It is used in the preparation of hibarimicinone, (Z)-silylketene acetal and 4-substituted quinazoline. It acts as a precursor to Lithium tetramethylpiperidide and (2,2,6,6-Tetramethylpiperidin-1-yl)oxyl radical. | | Uses | 2,2,6,6-Tetramethylpiperidine is used in the syntheses of HMP-Y1, Hibarimicinone and HMP-P1, tyrosine kinase inhibitors. | | Uses | The lithium amide has been used to efficiently ortho deprotonate pyridine-3-carboxamides. | | Preparation | Many routes for the synthesis of TMP have been reported. One method starts with a conjugate addition reaction of ammonia to phorone. The intermediate triacetone amine is then reduced in a Wolff-Kishner reaction.
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| | 2,2,6,6-Tetramethylpiperidine Preparation Products And Raw materials |
| Preparation Products | 2-(TRIFLUOROMETHYL)-4-ISOCYANATOPYRIDINE-->5-FLUORO-2-PICOLINIC ACID-->2-CHLOROPYRIDINE-3,4-DICARBOXYLIC ACID-->2,2,6,6-Tetramethylpiperidinooxy-->3-BROMO-2-((CYCLOPROPYLAMINO)METHYL)BENZALDEHYDE-->6-CHLOROPYRIDINE-3,4-DICARBOXYLIC ACID-->4-(TRIFLUOROMETHYL)-2-(5,5-DIMETHYL-1,3,2-DIOXABORINAN-2-YL)BENZONITRILE-->2-CHLORO-6-(5,5-DIMETHYL-1,3,2-DIOXABORINAN-2-YL)BENZONITRILE-->2-BROMO-6-(5,5-DIMETHYL-1,3,2-DIOXABORINAN-2-YL)BENZONITRILE-->3-FLUORO-2-(5,5-DIMETHYL-1,3,2-DIOXABORINAN-2-YL)BENZONITRILE-->2-(3-METHOXYPHENYL)CYCLOHEXANONE-->5-(TRIFLUOROMETHYL)-2-(5,5-DIMETHYL-1,3,2-DIOXABORINAN-2-YL)BENZONITRILE-->2-CYANO-5-BROMOPHENYLBORONIC ACID PINACOL ESTER-->2-(TRIFLUOROMETHYL)-6-(5,5-DIMETHYL-1,3,2-DIOXABORINAN-2-YL)BENZONITRILE-->(E)-5-(2-CARBOXYVINYL)-2,4-DIMETHOXYPYRIMIDINE-->2-Chloro-4-methoxypyrimidine-5-carbaldehyde-->4-CHLORO-2-(5,5-DIMETHYL-1,3,2-DIOXABORINAN-2-YL)BENZONITRILE-->2-METHOXY-6-(5,5-DIMETHYL-1,3,2-DIOXABORINAN-2-YL)BENZONITRILE-->3-METHOXY-2-(5,5-DIMETHYL-1,3,2-DIOXABORINAN-2-YL)BENZONITRILE-->5-FORMYL-2,4-DIMETHOXYPYRIMIDINE-->3-CYANOPYRIDIN-4-YLBORONIC ACID-->4-CYANOPYRIDIN-3-YLBORONIC ACID-->2-CYANOPYRIDIN-3-YLBORONIC ACID |
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