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| | 2'-Fluoro-2'-deoxyuridine Basic information |
| | 2'-Fluoro-2'-deoxyuridine Chemical Properties |
| Melting point | 147.0 to 153.0 °C | | density | 1.63±0.1 g/cm3(Predicted) | | refractive index | 53 ° (C=0.3, H2O) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | solubility | Soluble in methanol. | | form | Powder | | pka | 9.39±0.10(Predicted) | | color | White to Off-white | | InChI | InChI=1S/C9H11FN2O5/c10-6-7(15)4(3-13)17-8(6)12-2-1-5(14)11-9(12)16/h1-2,4,6-8,13,15H,3H2,(H,11,14,16)/t4-,6-,7-,8-/m1/s1 | | InChIKey | UIYWFOZZIZEEKJ-XVFCMESISA-N | | SMILES | OC[C@H]1O[C@@H](N2C=CC(=O)NC2=O)[C@H](F)[C@@H]1O | | CAS DataBase Reference | 784-71-4(CAS DataBase Reference) |
| | 2'-Fluoro-2'-deoxyuridine Usage And Synthesis |
| Description | 2'-Deoxy-2'-fluorouridine is a nucleoside analog that inhibits the replication of wild-type viruses by binding to the viral RNA. 2'-Deoxy-2'-fluorouridine has been shown to inhibit the replication of resistant mutants in vitro, and this inhibition can be reversed by increasing the concentration of 2'-deoxy-2'-fluorouridine. 2'-Deoxy-2'-fluorouridine also binds to duplexes of dsDNA with high affinity and specificity. | | Chemical Properties | White to almost white crystalline powder | | Uses | A component incorporated into therapeutic oligonucleotides to combat prostate and breast cancer. | | Uses | 2'-Fluoro-2'-deoxyuridine is used as a component incorporated into therapeutic oligonucleotides to combat prostate and breast cancer. |
| | 2'-Fluoro-2'-deoxyuridine Preparation Products And Raw materials |
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