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| | NU 6027 Basic information |
| Product Name: | NU 6027 | | Synonyms: | 2,4-Pyrimidinediamine, 6-(cyclohexylmethoxy)-5-nitroso-;ATR/CDK Inhibitor, NU6027;2,6-DiaMino-4-(cyclohexylMethoxy)-5-nitrosopyriMidine;ATR/CDK Inhibitor, NU6027 - CAS 220036-08-8 - Calbiochem;NU6027;NU-6027;NU 6027;6-(cyclohexylmethoxy)-5-nitrosopyrimidine-2,4-diamine;NU 6027 USP/EP/BP;inhibit,Ataxia telangiectasia mutated,Cyclin dependent kinase,ATM/ATR,NU 6027,cytotoxicity,NU6027,Inhibitor,NU-6027,CDK2,cisplatin,hydroxyurea,ATR,CDK1,CDK,ATM and RAD3 related,cancer | | CAS: | 220036-08-8 | | MF: | C11H17N5O2 | | MW: | 251.29 | | EINECS: | | | Product Categories: | Inhibitors | | Mol File: | 220036-08-8.mol |  |
| | NU 6027 Chemical Properties |
| Melting point | 252.5-253.7 °C(lit.) | | Boiling point | 549.2±60.0 °C(Predicted) | | density | 1.53±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO: 15 mg/mL | | pka | 2.52±0.10(Predicted) | | form | Reddish-purple powder | | color | lavender |
| | NU 6027 Usage And Synthesis |
| Uses | NU6027 is a potent cyclin-dependent kinase (CDK) and Rad3-related kinase (ATR) inhibitor. NU6027 has been shown to inhibit tumor cell growth. NU6027 inhibits ATR, impairing G2/M arrest and homologous recombination thus increasing sensitivity to DNA-damaging agents and poly(ADP-ribose) polymerase (PARP) inhibitors | | target | CDK1 |
| | NU 6027 Preparation Products And Raw materials |
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