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| Product Name: | DEPMPO | | Synonyms: | (2-METHYL-3,4-DIHYDRO-1-OXIDE-2H-PYRROL-2-YL)DIETHYLPHOSPHONATE;2-DIETHYLPHOSPHONO-2-METHYL-3,4-DIHYDRO-2H-PYRROLE 1-OXIDE;5-(DIETHYLPHOSPHONO)-5-METHYL-1-PYRROLINE N-OXIDE;5-(DIETHOXYPHOSPHONYL)-5-METHYL-1-PYRROLINE-N-OXIDE;5-(DIETHOXYPHOSPHORYL)-5-METHYL-1-PYRROLINE-N-OXIDE;5-(Diethoxyphosphoryl)-;P-(3,4-Dihydro-2-Methyl-1-oxido-2H-pyrrol-2-yl)phosphonic Acid Diethyl Ester;(3,4-Dihydro-2-methyl-1-oxido-2H-pyrrol-2-yl)-phosphonic acid diethyl ester | | CAS: | 157230-67-6 | | MF: | C9H18NO4P | | MW: | 235.22 | | EINECS: | | | Product Categories: | Spin Labeling Compounds;Analytical Chemistry;ESR Spectrometry;Spin Trapping Reagents | | Mol File: | 157230-67-6.mol |  |
| | DEPMPO Chemical Properties |
| Boiling point | 412.4±34.0 °C(Predicted) | | density | 1.14±0.1 g/cm3(Predicted) | | storage temp. | Freezer | | solubility | Soluble in Water or Ethanol. | | form | Colorless to light yellow oil. | | pka | 1.74±0.40(Predicted) | | color | Pale yellow | | Stability: | Hygroscopic Oil, Light Sensitive |
| | DEPMPO Usage And Synthesis |
| Description | DEPMPO (157230-67-6) is a spin trap capable of detecting oxygen, nitrogen, sulfur and carbon-centered free radicals both in vitro and in vivo. DEPMPO is useful for distinguishing between superoxide-dependent pathways of hydroxyl radical generation, and those that are superoxide independent. | | Chemical Properties | DEPMPO is Pale Yellow Oil | | Uses | DEPMPO is a spin trap useful as a probe for free radical formation during myocardial ischemia/reperfusion injury. An analogue of DMPO | | Uses | DEPMPO is the most efficient spin trap for the in vitro detection of O-, N-, S- and C-centered free radicals both invitro and invivo. It has a longer life-time than DMPO and can distinguish between superoxide-dependent and independent mechanisms that lead to the hydroxyl radical. It is less lipophilic (Kp=0.16) than DIPPMPO. | | References | 1) Liu et al. (1999), Evaluation of DEPMPO as a spin trapping agent in biological systems; Free Radic. Biol. Med., 26 714
2) Shi et al. (2005), Evaluation of spin trapping agents and trapping conditions for detection of cell-generated reactive oxygen species; Arch. Biochem. Biophys., 437 59
3) Culcasi et al. (2012), EPR spin trapping evaluation of ROS production in human fibroblasts exposed to cerium oxide nanoparticles: evidence for NADPH oxidase and mitochondrial stimulation; Chem. Biol. Interact., 199 161
4) Tampieri et al. (2019), Comment on “Water Soluble Fluorescent Probe with Dual Mitochondria/Lysosome Targetability for Selective Superoxide Detection in Live Cells and in Zebrafish Embryos; ACS Sens. E-pub. Ahead of Print [Focus Citation] |
| | DEPMPO Preparation Products And Raw materials |
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