ChemicalBook > Product Catalog >API >Circulatory system drugs >Antiarrhythmics Drugs >Atenolol

Atenolol

Atenolol Suppliers list
Company Name: Shenzhen Sendi Biotechnology Co.Ltd.
Tel: 0755-23311925 18102838259
Email: Abel@chembj.com
Products Intro: Product Name:Atenolol
CAS:29122-68-7
Purity:99% Package:308/KG
Company Name: Wuhan Wsem Biological Co., Ltd.  Gold
Tel:027-59402396 ; 13419635609
Email:13419635609@163.com
Products Intro:Product Name:Atenolol
CAS:29122-68-7
Purity:99.9% Package:1G 50G 1KG 25KG
Company Name: J & K SCIENTIFIC LTD.  
Tel:400-666-7788 +86-10-82848833
Email:jkinfo@jkchemical.com;market6@jkchemical.com
Products Intro:Product Name:Atenolol
CAS:29122-68-7
Purity:98% Package:1G
Company Name: 3B Pharmachem (Wuhan) International Co.,Ltd.  
Tel:86-21-50328103 * 801、802、803、804 Mobile:18930552037
Email:3bsc@sina.com
Products Intro:Product Name:(RS)-Atenolol;(RS)-4-[2-Hydroxy-3-[(1-Methylethyl)aMino]propoxy]benzeneacetaMide
CAS:29122-68-7
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
Company Name: Energy Chemical  
Tel:021-58432009 / 400-005-6266
Email:info@energy-chemical.com
Products Intro:Product Name:Atenolol
CAS:29122-68-7
Purity:98% Package:10G
Atenolol Basic information
Pharmacological Affects Chemical Property Uses
Product Name:Atenolol
Synonyms:noten;(RS)-ATENOLOL;(RS)-4-[2-HYDROXY-3-[(1-METHYLETHYL)AMINO]PROPOXY]BENZENEACETAMIDE;TENORMIN;tenlol;1-p-carbamoylmethylphenoxy-3-isopropylamino-2-propanol;2-(p-(2-hydroxy-3-(isopropylamino)propoxy)phenyl)-acetamid;2-(p-(2-hydroxy-3-(isopropylamino)propoxy)phenyl)acetamide
CAS:29122-68-7
MF:C14H22N2O3
MW:266.34
EINECS:249-451-7
Product Categories:Pharmaceutical;Intermediates & Fine Chemicals;Pharmaceuticals;API's;Adrenoceptor;Amines;Aromatics;API;Isotope;TENORMIN;Other APIs
Mol File:29122-68-7.mol
Atenolol Structure
Atenolol Chemical Properties
Melting point 154°C
Fp 2℃
storage temp. Store at RT
solubility H2O: 0.3 mg/mL
form powder
pka9.6(at 25℃)
color white to off-white
Merck 14,859
CAS DataBase Reference29122-68-7(CAS DataBase Reference)
NIST Chemistry ReferenceAtenolol(29122-68-7)
Safety Information
Hazard Codes Xn,F
Risk Statements 22-36/37/38-20/21/22-36-11
Safety Statements 22-24/25-36-26-36/37-16
RIDADR UN 1648 3 / PGII
WGK Germany 2
RTECS AC3600000
HazardClass IRRITANT
HS Code 29242995
Hazardous Substances Data29122-68-7(Hazardous Substances Data)
MSDS Information
ProviderLanguage
Tenormin English
SigmaAldrich English
Atenolol Usage And Synthesis
Pharmacological AffectsAtenolol ,also known as atenolol, Aten Yue Er, tamoxifen, downhill Ling blood pressure, Tenormin, blood pressure Ling, is a long-acting cardioselective β1-adrenergic blockers, without intrinsic sympathomimetic activity or membrane stability.The atenolol,s retardation for β1 adrenaline receptors is similar with metoprolol, propranolol and nadolol , which is 1/6 times for pindolol and timolol. But, it does not inhibit the effect of the isoproterenol bronchodilator.When administered in small doses, it does not like non-selective β-adrenergic blockers as aggravated hypoglycemia induced hypertensive crisis, peripheral circulatory impairment or patients with obstructive airways disease worsening airway function and so on. However, When administered in large doses, atenolol also can decrease asthma or chronic obstructive pulmonary disease, airway function. Atenolol, as a long-term treatment of hypertension, also were reported for affecting airway function. Thus, despite atenolol heart selection, chronic obstructive pulmonary disease patients can only use small doses, but also should be given a sufficient amount of β1-adrenergic receptor agonists.
Oral F is 46%~60%, Tmax about 2~4 h, Mainly unchanged since the urine excretion, T1/2 of 6~7 h. Hemodialysis can clear the goods. Rapidly absorbed from the gastrointestinal tract, but not exclusively.The rest of the body is excreted in the stool. Food can reduce the F, fasting and after meals AUC decreased by 20%. Distribution of the central nervous system is relatively few. The ratio of brain tissue to blood concentration was 0.1:1. Easy to achieve in the placenta and the maternal plasma concentrations of same. PPB is less than 5%, Vd is 50~75 L. Atenolol is not metabolized by the liver, most of the drug is excreted from the body in urine, renal insufficiency in patients with T1/2 was significantly prolonged. Patients with renal failure range of T1/2 was 10~28 h, or even up to 100 h. Results at 24 h after, the discharge from the urine of the drug can be reduced by 29%. The T1/2 of patients with hyperthyroidism was significantly shortened, 4.2h.
The above information is edited by the chemicalbook of Kui Ming.
Chemical PropertyWhite powder. Melting point (146-148 ℃). Soluble in alcohol, slightly soluble in water, chloroform, Hardly soluble in ethyl ether, slightly smelly.
Usesβ-blockers. Clinical application in the treatment of hypertension, angina and arrhythmia.
Chemical PropertiesCrystalline Solid
UsesCardioselective ?adrenergic blocker. Antihypertensive, antianginal, antiarrhythmic (class II)
UsesCardioselective β-adrenergic blocker. Antihypertensive, antianginal, antiarrhythmic (class II).
Usesbeta adrenergic blocker
UsesSelective b1 adrenergic receptor agonist, anti-hypertensive, anti-anginal, anti-arrhythmic
UsesAntihypertensive, Beta-adrenoceptor antagonist
DefinitionChEBI: An ethanolamine compound having a (4-carbamoylmethylphenoxy)methyl group at the 1-position and an N-isopropyl substituent.
Biological ActivityCardioselective β -adrenergic blocker. Antihypertensive, antianginal, antiarrhythmic.
Atenolol Preparation Products And Raw materials
Raw materials4'-Hydroxyacetophenone
Tag:Atenolol(29122-68-7) Related Product Information
ATENOLOL IMP. B (EP): 2-[4-(2,3-DIHYDROXYPROPOXY)PHENYL]ACETAMIDE MM(CRM STANDARD) ATENOLOL IMPURITY C S(-)-ATENOLOL >96% ACTIVE ENANTIOMER OF,S(-)-ATENOLOL ATENOLOL IMPURITY F ATENOLOL, [RING-3H]- R(+)-ATENOLOL LESS ACTIVE ENANTIOME,(R)-(+)-ATENOLOL ATENOLOL-D7 (ISO-PROPYL-D7) Atenolol 2-HYDROXYACETAMIDE AMINO ACIDS Methoxydiethylborane p-(2-Methoxyethyl) phenol Betaine CHLOROPHOSPHONAZO III ALTRENOGEST Glycine Thioacetamide Acetamide