| | PROTOVERATRINE A Basic information |
| Product Name: | PROTOVERATRINE A | | Synonyms: | PROTOVERATRINE A;6,7-diacetate3-((+)-2-hydroxy-2-methylbutyrate)15-((-)-2-methylbutyrate);protalba;protoveratrin;[3beta(S),4alpha,6alpha,7alpha,15alpha(R),16beta]-4,9-epoxycevane-3,4,6,7,14,15,16,20-octol 6,7-diacetate 3-(2-hydroxy-2-methylbutyrate) 15-(2-methylbutyrate);4α,9-Epoxycevane-3β,4,6α,7α,14,15α,16β,20-octol 6,7-diacetate 3-[(S)-2-hydroxy-2-methylbutanoate]15-[(R)-2-methylbutanoate];Puroverine;Cevane-3,4,6,7,14,15,16,20-octol, 4,9-epoxy-, 6,7-diacetate 3-(2-hydroxy-2-methylbutanoate) 15-(2-methylbutanoate), [3.beta.(S),4.alpha.,6.alpha.,7.alpha.,15.alpha.(R),16.beta.]- | | CAS: | 143-57-7 | | MF: | C41H63NO14 | | MW: | 793.94 | | EINECS: | 205-602-9 | | Product Categories: | Miscellaneous Natural Products | | Mol File: | 143-57-7.mol |  |
| | PROTOVERATRINE A Chemical Properties |
| Melting point | 267-269°C | | alpha | D25 -40.5° (pyridine); D25 -10.5° (chloroform) | | Boiling point | 747.91°C (rough estimate) | | density | 1.36±0.1 g/cm3 (20 ºC 760 Torr) | | refractive index | 1.6220 (estimate) | | storage temp. | 2-8°C | | solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | | form | powder | | pka | 10.74±0.70(Predicted) | | color | White |
| Hazard Codes | T+ | | Risk Statements | 26/27/28 | | Safety Statements | 22-36/37/39-45 | | RIDADR | UN 1544 6.1/PG 1 | | WGK Germany | 3 | | RTECS | FL5750100 | | HazardClass | 6.1(a) | | PackingGroup | I | | Toxicity | LD50 s.c. in male mice: 0.29 mg/kg (Tanaka) |
| | PROTOVERATRINE A Usage And Synthesis |
| Description | A further alkaloid isolated from Veratrum album, this base yields colourless
crystals from EtOH. It is laevorotatory with [α]27D - 44.1° (pyridine) or - 12.1°
(CHC13). Like the preceding base, it dissolves in H2S04 to give a blue colour.
The complex with maleic acid has been prepared as colourless crystals, m.p.
241.5°C; [α]20D - 37.6°. On alkaline hydrolysis, the alkaloid furnishes protoverine, two moles of acetic acid, one mole of (-)-methylbutyric acid and one
mole of (+)-2-hydroxy-2-methylbutyric acid. | | Uses | Protoveratrine A is a pharmacological agent which displays neuroprotective effects in ischemic stroke. | | Definition | ChEBI: Protoveratrine A is an alkaloid. | | Brand name | Protalba (Marion Merrell Dow). | | target | Calcium Channel | Potassium Channel | | References | Stoll, Seebeck., Helv. Chim. Acta, 36,718 (1953) |
| | PROTOVERATRINE A Preparation Products And Raw materials |
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