|
|
| | KARAKOLINE Basic information |
| Product Name: | KARAKOLINE | | Synonyms: | (16S)-20-Ethyl-16-methoxy-4-methylaconitane-1α,8,14α-triol;Karacoline;Aconitane-1,8,14-triol,20-ethyl-16-methoxy-4-methyl-, (1a,14a,16b)-;Aconitane-1,8,14-triol, 20-ethyl-16-methoxy-4-methyl-, (1α,14α,16β)-;Carmicheline(7CI);11aH-12,3,6a-Ethanylylidene-7,9-methanonaphth[2,3-b]azocine, aconitane-1,8,14-triolderiv.;(1α,14α,16β)-20-Ethyl-16-methoxy-4-methylaconitane-1,8,14-triol;Inhibitor,Karacoline,inhibit | | CAS: | 39089-30-0 | | MF: | C22H35NO4 | | MW: | 377.52 | | EINECS: | | | Product Categories: | Alkaloids;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract | | Mol File: | 39089-30-0.mol |  |
| | KARAKOLINE Chemical Properties |
| Melting point | 185-186℃ (acetone ) | | Boiling point | 540.2±50.0 °C(Predicted) | | density | 1.30±0.1 g/cm3 (20 ºC 760 Torr) | | storage temp. | 2-8°C | | pka | 13.80±0.70(Predicted) |
| | KARAKOLINE Usage And Synthesis |
| Description | A second atisine base found in the tubers of Aconitum karacolicum, the structure
has been elucidated from chemical and spectroscopic data. Oxidation with
KMn04 gives anhydroepoxykaracoline. The alkaloid furnishes a triacetyl deriva_x0002_tive which, after pyrolysis and hydrolysis, yields acetyldemethylisopyrokaracoline. | | Uses | Karacoline is an Aconitane (A189875) derivative, which is a neurotoxin which activates tetrodotoxin-sensitive Na+ channels, inducing presynaptic depolarization, thus blocking the nerve action potential which, in turn, blocks the release of neurotransmitters and decreases the end plate potential at the neuromuscular junction. | | Definition | ChEBI: An organonitrogen heterocyclic compound that is aconitane bearing hydroxy groups at the 1alpha, 8, and 14alpha positions and substituted at on the nitrogen and at positions 4 and 16beta by ethyl, methyl, a
d methoxy groups, respectively. | | References | Sultankhodzhaev, Yunusov, Yunusov., Khim. Prir. Soedin., 9, 199 (1973) |
| | KARAKOLINE Preparation Products And Raw materials |
|