菜蓟苦素
| 中文名称 | 菜蓟苦素 |
|---|---|
| 中文同义词 | 菜蓟苦素 |
| 英文名称 | cynaropicrin |
| 英文同义词 | 2-Hydroxymethylpropenoic acid (3aR,4S,6aβ,9aβ,9bα)-dodecahydro-8α-hydroxy-3,6,9-tris(methylene)-2-oxoazuleno[4,5-b]furan-4-yl ester;Cynaropikrin;[(3aR,4S,6aR,8S,9aR,9bR)-8-hydroxy-3,6,9-trimethylidene-2-oxo-3a,4,5,6a,7,8,9a,9b-octahydroazuleno[4,5-b]furan-4-yl] 2-(hydroxymethyl)prop-2-enoate;2-methylolacrylic acid [(3aR,4S,6aR,8S,9aR,9bR)-8-hydroxy-2-keto-3,6,9-trimethylene-3a,4,5,6a,7,8,9a,9b-octahydroazuleno[4,5-b]furan-4-yl] ester;CYNAROPICRIN(SH);cynaropicrin;Cynaropicrin - Cynara cardunculus (artichoke);2-Propenoic acid, 2-(hydroxymethyl)-, (3aR,4S,6aR,8S,9aR,9bR)-dodecahydro-8-hydroxy-3,6,9-tris(methylene)-2-oxoazuleno[4,5-b]furan-4-yl ester |
| CAS号 | 35730-78-0 |
| 分子式 | C19H22O6 |
| 分子量 | 346.37 |
| EINECS号 | |
| 相关类别 | 植物提取物;对照品;对照品;标准品-对照品;标准品，对照品 |
| Mol文件 | 35730-78-0.mol |
| 结构式 |  |
菜蓟苦素 性质
| 沸点 | 566.2±50.0 °C(Predicted) |
|---|---|
| 密度 | 1.28±0.1 g/cm3 (20 ºC 760 Torr) |
| 储存条件 | -20°C, protect from light |
| 溶解度 | DMSO:50.0(最大浓度 mg/mL);144.35(最大浓度 mM) |
| 酸度系数(pKa) | 13.52±0.10(Predicted) |
| LogP | 1.340 (est) |
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MMP13
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NF-κB
|
TNF-α
|
Cynaropicrin strongly inhibits lipopolysaccharide-induced TNF-α release from either murine or human macrophage cells in a dose-dependent manner with the IC 50 values of 8.24 and 3.18 μM, respectively. Cynaropicrin shows significant inhibitory effects toward all mitogenic signals with the IC 50 values of 1.20 (concanavalin A), 1.02 (phytohemagglutinin) and 0.90 μM (lipopolysaccharide), respectively. Cynaropicrin suppresses CTLL-2 cell proliferation in a dose-dependent manner and the 50% inhibitory concentration (IC 50 ) of Cynaropicrin for CTLL-2 cell growth is 0.91 μM. The increased mRNA expression of MMP13 induced by TNF-α is similarly inhibited in a concentration-dependent manner by Cynaropicrin. The increased mRNA expression of HIF-2α induced by IL-1β in SW1353 is inhibited in a concentration-dependent manner by Cynaropicrin.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-N2350 | Cynaropicrin | 1 mg | 480元 | |
| 2024/01/25 | HY-N2350 | 菜蓟苦素 Cynaropicrin | 35730-78-0 | 5mg | 1180元 |