| Company Name: |
Haoyuan Chemexpress Co., Ltd.
|
| Tel: |
021-58950125 |
| Email: |
info@chemexpress.com |
| Products Intro: |
Product Name:USP7-IN-1
CAS:1381291-36-6
Purity:>98% Package:2333RMB/2mg
|
| Company Name: |
MedChemexpress LLC
|
| Tel: |
021-58955995 |
| Email: |
sales@medchemexpress.cn |
| Products Intro: |
Product Name:USP7-IN-1
CAS:1381291-36-6
Purity:>98% Package:2333RMB/2mg
|
|
| | USP7-IN-1 Basic information |
| Product Name: | USP7-IN-1 | | Synonyms: | USP7-IN-1;4(3H)-Quinazolinone, 7-chloro-3-[[4-hydroxy-1-(1-oxo-3-phenylpropyl)-4-piperidinyl]methyl]-;USP7i-1;USP7 inhibitor 1;Inhibitor,inhibit,USP-7-IN-1,USP7IN1,USP7 IN 1,DUBs,Deubiquitinase | | CAS: | 1381291-36-6 | | MF: | C23H24ClN3O3 | | MW: | 425.91 | | EINECS: | | | Product Categories: | | | Mol File: | 1381291-36-6.mol |  |
| | USP7-IN-1 Chemical Properties |
| Boiling point | 666.2±65.0 °C(Predicted) | | density | 1.32±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO: ≥ 40 mg/mL (93.92 mM) | | pka | 13.52±0.20(Predicted) |
| | USP7-IN-1 Usage And Synthesis |
| Description | USP7-IN-1 is a selective and reversible inhibitor of ubiquitin-specific protease 7 (USP7), with an IC50 of 77 μM, and can be used for the research of cancer.
IC50: 77 μM (USP7)[1] USP7-IN-1 (Example 2) is a selective and reversible inhibitor of USP7, with an IC50 of 77 μM, and shows no inhibition of USP8, USP5, Uch-L1, Uch-L3 or caspase 3. USP7-IN-1 inhibits the proliferation of HCT116 cells, with a GI50 of 67 μM[1]. | | References | [1]. SELECTIVE AND REVERSIBLE INHIBITORS OF UBIQUITIN SPECIFIC PROTEASE 7. WO 2013030218 A1 |
| | USP7-IN-1 Preparation Products And Raw materials |
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